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  • Synthesis of N-substituted acridinediones and polyhydroquinoline derivatives in refluxing water.

Synthesis of N-substituted acridinediones and polyhydroquinoline derivatives in refluxing water.

Molecules (Basel, Switzerland) (2012-05-09)
Jing-Jing Xia, Ke-Hua Zhang
ABSTRACT

Acridinediones were synthesized by the one-pot Hantzsch condensation of an aromatic aldehyde, 5,5-dimethyl-1,3-cyclohexanedione, and aniline/4-methylaniline in refluxing water. This method has then been extended to the four-component reaction of an aromatic aldehyde, 5,5-dimethyl-1,3-cyclohexanedione, ethyl acetoacetate and ammonium acetate for the synthesis of polyhydroquinoline derivatives. This is an environmentally friendly and efficient procedure providing  good to excellent yields.

MATERIALS
Product Number
Brand
Product Description

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