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  • Solid state grinding as a tool to aid enantiomeric resolution by cocrystallisation.

Solid state grinding as a tool to aid enantiomeric resolution by cocrystallisation.

Chemical communications (Cambridge, England) (2012-10-18)
Mark D Eddleston, Mihails Arhangelskis, Tomislav Friščić, William Jones
PMID23073186
ABSTRACT

The formation of diastereomeric cocrystals of malic acid and tartaric acid was investigated by liquid-assisted grinding in the solid state. We demonstrate that racemic malic acid can be converted into two distinct diastereomeric cocrystal phases by grinding with a single enantiomer of tartaric acid.

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