Skip to Content
MilliporeSigma
  • Maternal first-trimester diet and childhood bone mass: the Generation R Study.

Maternal first-trimester diet and childhood bone mass: the Generation R Study.

The American journal of clinical nutrition (2013-05-31)
Denise H M Heppe, Carolina Medina-Gomez, Albert Hofman, Oscar H Franco, Fernando Rivadeneira, Vincent W V Jaddoe
ABSTRACT

Maternal diet during pregnancy has been suggested to influence bone health in later life. We assessed the association of maternal first-trimester dietary intake during pregnancy with childhood bone mass. In a prospective cohort study in 2819 mothers and their children, we measured first-trimester daily energy, protein, fat, carbohydrate, calcium, phosphorus, and magnesium intakes by using a food-frequency questionnaire and homocysteine, folate, and vitamin B-12 concentrations in venous blood. We measured childhood total body bone mass by using dual-energy X-ray absorptiometry at the median age of 6.0 y. Higher first-trimester maternal protein, calcium, and phosphorus intakes and vitamin B-12 concentrations were associated with higher childhood bone mass, whereas carbohydrate intake and homocysteine concentrations were associated with lower childhood bone mass (all P-trend < 0.01). Maternal fat, magnesium intake, and folate concentrations were not associated with childhood bone mass. In the fully adjusted regression model that included all dietary factors significantly associated with childhood bone mass, maternal phosphorus intake and homocysteine concentrations most-strongly predicted childhood bone mineral content (BMC) [β = 2.8 (95% CI: 1.1, 4.5) and β = -1.8 (95% CI: -3.6, 0.1) g per SD increase, respectively], whereas maternal protein intake and vitamin B-12 concentrations most strongly predicted BMC adjusted for bone area [β = 2.1 (95% CI: 0.7, 3.5) and β = 1.8 (95% CI: 0.4, 3.2) g per SD increase, respectively]. Maternal first-trimester dietary factors are associated with childhood bone mass, suggesting that fetal nutritional exposures may permanently influence bone development.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Magnesium, chips, 6-35 mesh, 99.98% trace metals basis
Sign Into View Organizational & Contract Pricing
SKUPack SizeAvailabilityPriceQuantity
25 g
In Stock
Details...
$40.10
100 g
In Stock
Details...
$116.00
$81.20
Sigma-Aldrich
Magnesium, ReagentPlus®, powder, −50 mesh, ≥99%
Sign Into View Organizational & Contract Pricing
SKUPack SizeAvailabilityPriceQuantity
25 g
In Stock
Details...
$40.10
100 g
In Stock
Details...
$116.00
$81.20
Sigma-Aldrich
Magnesium, turnings, 5-25 mm, 99.95% trace metals basis
Sign Into View Organizational & Contract Pricing
SKUPack SizeAvailabilityPriceQuantity
25 g
In Stock
Details...
$40.10
100 g
In Stock
Details...
$116.00
$81.20
Sigma-Aldrich
Magnesium preparation, Highly Reactive Rieke® Metal, suspension, 2.5 g in THF
Sign Into View Organizational & Contract Pricing
SKUPack SizeAvailabilityPriceQuantity
25 g
In Stock
Details...
$40.10
100 g
In Stock
Details...
$116.00
$81.20
Sigma-Aldrich
Magnesium, grit, ≥99.0% (KT)
Sign Into View Organizational & Contract Pricing
SKUPack SizeAvailabilityPriceQuantity
25 g
In Stock
Details...
$40.10
100 g
In Stock
Details...
$116.00
$81.20
Sigma-Aldrich
Magnesium, ribbon, ≥99.0% Mg basis
Sign Into View Organizational & Contract Pricing
SKUPack SizeAvailabilityPriceQuantity
25 g
In Stock
Details...
$40.10
100 g
In Stock
Details...
$116.00
$81.20
Sigma-Aldrich
Magnesium, powder, ≥99%
Sign Into View Organizational & Contract Pricing
SKUPack SizeAvailabilityPriceQuantity
25 g
In Stock
Details...
$40.10
100 g
In Stock
Details...
$116.00
$81.20
Sigma-Aldrich
Magnesium, purum, for Grignard reactions, ≥99.5%, turnings
Sign Into View Organizational & Contract Pricing
SKUPack SizeAvailabilityPriceQuantity
25 g
In Stock
Details...
$40.10
100 g
In Stock
Details...
$116.00
$81.20
Sigma-Aldrich
Magnesium, turnings, reagent grade, 98%
Sign Into View Organizational & Contract Pricing
SKUPack SizeAvailabilityPriceQuantity
25 g
In Stock
Details...
$40.10
100 g
In Stock
Details...
$116.00
$81.20
Sigma-Aldrich
Magnesium, dendritic pieces, purified by distillation, 99.998% trace metals basis
Sign Into View Organizational & Contract Pricing
SKUPack SizeAvailabilityPriceQuantity
25 g
In Stock
Details...
$40.10
100 g
In Stock
Details...
$116.00
$81.20
Sigma-Aldrich
Magnesium, rod, diam. 6 mm, ≥99.9% trace metals basis
Sign Into View Organizational & Contract Pricing
SKUPack SizeAvailabilityPriceQuantity
25 g
In Stock
Details...
$40.10
100 g
In Stock
Details...
$116.00
$81.20
Sigma-Aldrich
Magnesium, ReagentPlus®, ribbon, ≥99% trace metals basis
Sign Into View Organizational & Contract Pricing
SKUPack SizeAvailabilityPriceQuantity
25 g
In Stock
Details...
$40.10
100 g
In Stock
Details...
$116.00
$81.20
Sigma-Aldrich
Magnesium, ReagentPlus®, powder, −325 mesh, 99.5% trace metals basis
Sign Into View Organizational & Contract Pricing
SKUPack SizeAvailabilityPriceQuantity
25 g
In Stock
Details...
$40.10
100 g
In Stock
Details...
$116.00
$81.20
Sigma-Aldrich
Vitamin B12, BioReagent, suitable for cell culture, suitable for insect cell culture, suitable for plant cell culture, ≥98%
Sign Into View Organizational & Contract Pricing
SKUPack SizeAvailabilityPriceQuantity
25 g
In Stock
Details...
$40.10
100 g
In Stock
Details...
$116.00
$81.20
Sigma-Aldrich
Vitamin B12, ≥98%
Sign Into View Organizational & Contract Pricing
SKUPack SizeAvailabilityPriceQuantity
25 g
In Stock
Details...
$40.10
100 g
In Stock
Details...
$116.00
$81.20
Sigma-Aldrich
Magnesium, in a Sure/Seal bottle, turnings, anhydrous tetrahydrofuran 37.5 mmol
Sign Into View Organizational & Contract Pricing
SKUPack SizeAvailabilityPriceQuantity
25 g
In Stock
Details...
$40.10
100 g
In Stock
Details...
$116.00
$81.20
Sigma-Aldrich
Magnesium, in a Sure/Seal bottle, turnings, 37.5 mmol
Sign Into View Organizational & Contract Pricing
SKUPack SizeAvailabilityPriceQuantity
25 g
In Stock
Details...
$40.10
100 g
In Stock
Details...
$116.00
$81.20
Sigma-Aldrich
Magnesium, 20-230 mesh, reagent grade, 98%
Sign Into View Organizational & Contract Pricing
SKUPack SizeAvailabilityPriceQuantity
25 g
In Stock
Details...
$40.10
100 g
In Stock
Details...
$116.00
$81.20
Sigma-Aldrich
Magnesium, wire, 127 μm diameter, 99.9% trace metals basis
Sign Into View Organizational & Contract Pricing
SKUPack SizeAvailabilityPriceQuantity
25 g
In Stock
Details...
$40.10
100 g
In Stock
Details...
$116.00
$81.20
Sigma-Aldrich
L-Homocysteine, ≥98.0% (NT)
Sign Into View Organizational & Contract Pricing
SKUPack SizeAvailabilityPriceQuantity
25 g
In Stock
Details...
$40.10
100 g
In Stock
Details...
$116.00
$81.20
Supelco
Cyanocobalamin (Vitamin B12) solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®
Sign Into View Organizational & Contract Pricing
SKUPack SizeAvailabilityPriceQuantity
25 g
In Stock
Details...
$40.10
100 g
In Stock
Details...
$116.00
$81.20
Supelco
Cyanocobalamin (B12), analytical standard
Sign Into View Organizational & Contract Pricing
SKUPack SizeAvailabilityPriceQuantity
25 g
In Stock
Details...
$40.10
100 g
In Stock
Details...
$116.00
$81.20
Supelco
Cyanocobalamin, pharmaceutical secondary standard, certified reference material
Sign Into View Organizational & Contract Pricing
SKUPack SizeAvailabilityPriceQuantity
25 g
In Stock
Details...
$40.10
100 g
In Stock
Details...
$116.00
$81.20
Sigma-Aldrich
Cyanocobalamin, tested according to Ph. Eur.
Sign Into View Organizational & Contract Pricing
SKUPack SizeAvailabilityPriceQuantity
25 g
In Stock
Details...
$40.10
100 g
In Stock
Details...
$116.00
$81.20
Sigma-Aldrich
Cyanocobalamin, meets USP testing specifications
Sign Into View Organizational & Contract Pricing
SKUPack SizeAvailabilityPriceQuantity
25 g
In Stock
Details...
$40.10
100 g
In Stock
Details...
$116.00
$81.20