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[Chemical constituents of Salvia chinensis].

[Chemical constituents of Salvia chinensis].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica (2013-08-21)

Jun-Feng Gao, Ling Ding, Peng Zhang, Jian-Xun Liu

ABSTRACT

Chemical constituents were investigated on the ethyl acetate extract of Salvia chinensis. Compounds were separated and purified by various chromatograhic techniques including silica gel, Sephadex LH-20 and reversed-phase HPLC. Their structures were identified by spectroscopic data analysis. Eleven compounds were isolated and purified and their structures were identified as oresbiusin A(1), ethyl dihydrocaffeate (2), ethyl rosmarinate (3), rosmarinic acid (4), methyl rosmarinate (5), bis (2-ethylhexyl) phthalate (6), salvianol acid C (7), methyl salvianol acid C (8), methyl salvianolate A (9), dimethyl lithospermate B (10), and salvianolic acid A(11). Except for rosmarinic acid, the remaining compounds were isolated from S. chinensis for the first time.

MATERIALS

Product Number

Brand

Product Description

Sigma-Aldrich

Sephadex^® G-50, BioReagent, for molecular biology, DNA grade, fine

Sigma-Aldrich

Sephadex^® G-50, BioReagent, for molecular biology, DNA grade, medium

Sigma-Aldrich

Sephadex^® G-50, Superfine

Supelco

Sephadex^® G-50, Medium

Sigma-Aldrich

Sephadex^® G-50, Fine

Supelco

Salvianolic acid A, analytical standard

Supelco

Dextran, analytical standard, for GPC, 25,000

Sigma-Aldrich

Dextran from Leuconostoc spp., M_r 15,000-25,000

Supelco

Dextran, analytical standard, for GPC, 5,000

Supelco

Dextran, analytical standard, for GPC, 12,000

Supelco

Dextran, analytical standard, for GPC, 270,000

Supelco

Dextran, analytical standard, for GPC, 1,000

Supelco

Dextran, analytical standard, for GPC, 410,000

Supelco

Dextran from Leuconostoc mesenteroides, analytical standard, for GPC, Mw 670,000

Supelco

Dextran from Leuconostoc mesenteroides, for GPC, analytical standard, Mw 50,000

Supelco

Dextran from Leuconostoc mesenteroides, analytical standard, for GPC, Mw 410,000

Supelco

Dextran, analytical standard, for GPC, Set M_p 1,000-400,000

Sigma-Aldrich

Dextran from Leuconostoc spp., M_r ~100,000

Sigma-Aldrich

Rosmarinic acid, 96%

Supelco

Dextran from Leuconostoc mesenteroides, analytical standard, for GPC, Mw 12,000

Supelco

Dextran from Leuconostoc mesenteroides, analytical standard, for GPC, Mw 1,000

Sigma-Aldrich

Dextran from Leuconostoc mesenteroides, M_r ~60,000

Sigma-Aldrich

Dextran from Leuconostoc spp., M_r ~6,000

Sigma-Aldrich

Dextran, enzymatic synth.

Sigma-Aldrich

Sephadex^® G-15, Medium

Sigma-Aldrich

Sephadex^® G-25, Coarse

Sigma-Aldrich

Sephadex^® G-25, Medium

Rosmarinic acid, primary reference standard

Sigma-Aldrich

Dextran from Leuconostoc mesenteroides, average mol wt 60,000-76,000

Sigma-Aldrich

Sephadex^® G-25, Fine