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  • From formamide to RNA: the roles of formamide and water in the evolution of chemical information.

From formamide to RNA: the roles of formamide and water in the evolution of chemical information.

Research in microbiology (2009-06-30)
Raffaele Saladino, Claudia Crestini, Fabiana Ciciriello, Samanta Pino, Giovanna Costanzo, Ernesto Di Mauro
ABSTRACT

In pursuing the origin of informational polymers, we followed the assumption that their spontaneous formation could only have occurred: (i) if all the components were present at the same site and in the same reaction, and (ii) if the thermodynamics of the processes involved favored a polymerized over a monomeric state of the precursors. A plausible scenario satisfying both assumptions is provided.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Formamide, ReagentPlus®, ≥99.0% (GC)
Sigma-Aldrich
Formamide, spectrophotometric grade, ≥99%
Sigma-Aldrich
Formamide, BioUltra, for molecular biology, ≥99.5% (T)
Sigma-Aldrich
Formamide, ACS reagent, ≥99.5%
Sigma-Aldrich
Formamide, BioReagent, ≥99.5% (GC), for molecular biology
Sigma-Aldrich
Formamide, JIS special grade, ≥98.5%
Sigma-Aldrich
Formamide, SAJ first grade, ≥98.5%