Skip to Content
MilliporeSigma
  • Long-term effect of specific treatment of primary aldosteronism on carotid intima-media thickness.

Long-term effect of specific treatment of primary aldosteronism on carotid intima-media thickness.

Journal of hypertension (2014-12-10)
Robert Holaj, Ján Rosa, Tomáš Zelinka, Branislav Štrauch, Ondřej Petrák, Tomáš Indra, Zuzana Šomlóová, David Michalský, Květoslav Novák, Dan Wichterle, Jiří Widimský
ABSTRACT

Aldosterone has been shown to substantially contribute to the accumulation of different types of collagen fibres and growth factors in the arterial wall, thus increasing wall thickness. A previous study showed reduction of increased common carotid intima-media thickness (IMT) in patients with primary aldosteronism 1 year after adrenalectomy. Our study in patients with primary aldosteronism was aimed at comparing the long-term effect of adrenalectomy vs. spironolactone therapy on common carotid IMT regression. Forty-two patients with confirmed primary aldosteronism (21 with aldosterone-producing adenoma treated by unilateral laparoscopic adrenalectomy, 21 treated with spironolactone) were investigated by carotid ultrasound at baseline and 1 and 6 years after the specific treatment. There was a decrease in common carotid IMT from 0.956 ± 0.140 to 0.900 ± 0.127 mm (-5.9%; P < 0.05) at 1 year and to 0.866 ± 0.130 mm (-9.4%; P < 0.01) at 6 years after adrenalectomy; in the spironolactone group, common carotid IMT decreased from 0.917 ± 0.151 to 0.900 ± 0.165 mm (-1.8%; NS) at 1 year and to 0.854 ± 0.176 mm (-6.8%; P < 0.01) at 6 years of treatment. The magnitude of improvement at 1 year was significantly higher (by 70%; P < 0.05) in the adrenalectomy group; however, the difference (by 27%) became nonsignificant at 6 years. Comparing the adrenalectomy and spironolactone groups, there was no significant difference in blood pressure decrease after treatment. In the long term, spironolactone therapy in patients with primary aldosteronism had significant effect on regression of IMT, which was comparable to surgical treatment in patients with unilateral forms of primary aldosteronism.

MATERIALS
Product Number
Brand
Product Description

Supelco
Cholesterol solution, certified reference material, 10 mg/mL in chloroform
SKU
Pack Size
Availability
Price
Quantity
Sigma-Aldrich
Cholesterol, powder, BioReagent, suitable for cell culture, ≥99%
SKU
Pack Size
Availability
Price
Quantity
Sigma-Aldrich
Hydrocortisone, γ-irradiated, powder, BioXtra, suitable for cell culture
SKU
Pack Size
Availability
Price
Quantity
Sigma-Aldrich
Hydrocortisone, ≥98% (HPLC)
SKU
Pack Size
Availability
Price
Quantity
Sigma-Aldrich
Cholesterol, from sheep wool, ≥92.5% (GC), powder
SKU
Pack Size
Availability
Price
Quantity
Sigma-Aldrich
Hydrocortisone, BioReagent, suitable for cell culture
SKU
Pack Size
Availability
Price
Quantity
Sigma-Aldrich
Cholesterol, Sigma Grade, ≥99%
SKU
Pack Size
Availability
Price
Quantity
Supelco
Hydrocortisone, Pharmaceutical Secondary Standard; Certified Reference Material
SKU
Pack Size
Availability
Price
Quantity
Sigma-Aldrich
Hydrocortisone, meets USP testing specifications
SKU
Pack Size
Availability
Price
Quantity
Hydrocortisone, British Pharmacopoeia (BP) Assay Standard
SKU
Pack Size
Availability
Price
Quantity
USP
Hydrocortisone, United States Pharmacopeia (USP) Reference Standard
SKU
Pack Size
Availability
Price
Quantity
Hydrocortisone, European Pharmacopoeia (EP) Reference Standard
SKU
Pack Size
Availability
Price
Quantity
SAFC
Cholesterol, from sheep wool, Controlled origin, meets USP/NF testing specifications
SKU
Pack Size
Availability
Price
Quantity
Supelco
Cholesterol, Pharmaceutical Secondary Standard; Certified Reference Material
SKU
Pack Size
Availability
Price
Quantity
Sigma-Aldrich
SyntheChol® NS0 Supplement, 500 ×, synthetic cholesterol, animal component-free, aqueous solution, sterile-filtered, suitable for cell culture
SKU
Pack Size
Availability
Price
Quantity
SAFC
Cholesterol, Plant-Derived, SyntheChol®
SKU
Pack Size
Availability
Price
Quantity
Hydrocortisone for peak identification, European Pharmacopoeia (EP) Reference Standard
SKU
Pack Size
Availability
Price
Quantity
Sigma-Aldrich
Aldosterone, ≥95% (HPLC)
SKU
Pack Size
Availability
Price
Quantity