- Multiple pathways facilitate the biogenesis of mammalian tail-anchored proteins.
Multiple pathways facilitate the biogenesis of mammalian tail-anchored proteins.
Journal of cell science (2017-10-13)
Joseph Casson, Michael McKenna, Sarah Haßdenteufel, Naama Aviram, Richard Zimmerman, Stephen High
PMID29021347
ABSTRACT
Tail-anchored (TA) proteins are transmembrane proteins with a single C-terminal transmembrane domain, which functions as both their subcellular targeting signal and membrane anchor. We show that knockout of TRC40 in cultured human cells has a relatively minor effect on endogenous TA proteins, despite their apparent reliance on this pathway
MATERIALS
Product Number
Brand
Product Description
Sigma-Aldrich
L-Glutamine solution, 200 mM, solution, sterile-filtered, BioXtra, suitable for cell culture
Sigma-Aldrich
Dulbecco′s Modified Eagle′s Medium - high glucose, With 4500 mg/L glucose, L-glutamine, sodium pyruvate, and sodium bicarbonate, liquid, sterile-filtered, suitable for cell culture