CHIROBIOTIC® phases are based on covalently bonding macrocyclic glycoproteins to a high-purity 5-micron silica gel in such a way as to establish its stability while retaining essential components for chiral recognition. CHIROBIOTIC® V and V2 are based on bonding Vancomycin, which contains 18 chiral centers surrounding three pockets or cavities. Five aromatic ring structures bridge these strategic cavities. Hydrogen donor-acceptor sites are readily available close to the ring structures. CHIROBIOTIC® V has demonstrated selectivity similar to glycoprotein phases except it is stable from 0-100% organic modifier and exhibits high sample capacity.
For CHIROBIOTIC® V2, changes to the linkage chemistry and silica offer improvements for preparative LC and for more demanding chiral separations. CHIROBIOTIC® T, T2, and TAG are based on bonding the amphoteric glycopeptide, Teicoplanin, which contains 23 chiral centers surrounding four pockets or cavities. For CHIROBIOTIC® T2, changes to the linkage chemistry and silica offer improvements for preparative LC and for more demanding chiral separations. CHIROBIOTIC® TAG has the sugars removed from the macrocyclic glycopeptide to produce an aglycone structure as a variant of CHIROBIOTIC® T. CHIROBIOTIC® R is based on bonding Ristocetin A to high purity 5-micron silica.
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