MAP3K8
mitogen-activated protein kinase kinase kinase 8
Synonyms:
COT, EST, ESTF, MEKK8, TPL2, Tpl-2, c-COT
สายพันธุ์:
Human MAP3K8 (1326), Mouse Map3k8 (26410), Rat Map3k8 (116596), naked mole-rat Map3k8 (101710286), cow MAP3K8 (535622), Zebrafish map3k8 (563727), chicken MAP3K8 (420479), dog MAP3K8 (487085), domestic cat MAP3K8 (101090624), Horse MAP3K8 (100063602) ...ดูเพิ่มเติม
UniProtKB ID:
รหัสยีน:
- Human(1326) Summary: This gene is an oncogene that encodes a member of the serine/threonine protein kinase family. The encoded protein localizes to the cytoplasm and can activate both the MAP kinase and JNK kinase pathways. This protein was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB. This protein was also found to promote the production of TNF-alpha and IL-2 during T lymphocyte activation. This gene may also utilize a downstream in-frame translation start codon, and thus produce an isoform containing a shorter N-terminus. The shorter isoform has been shown to display weaker transforming activity. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2011]
- Mouse(26410) mitogen-activated protein kinase kinase kinase 8
- Rat(116596) mitogen-activated protein kinase kinase kinase 8
- naked mole-rat(101710286) mitogen-activated protein kinase kinase kinase 8
- cow(535622) mitogen-activated protein kinase kinase kinase 8
- Zebrafish(563727) mitogen-activated protein kinase kinase kinase 8
- chicken(420479) mitogen-activated protein kinase kinase kinase 8
- dog(487085) mitogen-activated protein kinase kinase kinase 8
- domestic cat(101090624) mitogen-activated protein kinase kinase kinase 8
- Horse(100063602) mitogen-activated protein kinase kinase kinase 8
- sheep(101117094) mitogen-activated protein kinase kinase kinase 8
- Domestic Rabbit(100355566) mitogen-activated protein kinase kinase kinase 8
- domestic guinea pig(100725834) mitogen-activated protein kinase kinase kinase 8
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Antibodies
Product Number
คำอธิบาย
ความสามารถในการตอบสนองของสายพันธุ์
การใช้งาน
Anti-phospho-MAP3K8 (pSer400) antibody produced in rabbit, affinity isolated antibody,
ความสามารถในการตอบสนองของสายพันธุ์
human
การใช้งาน
immunohistochemistry
Anti-MAP3K8 antibody produced in rabbit, IgG fraction of antiserum,
ความสามารถในการตอบสนองของสายพันธุ์
bovine, dog, horse, human, rat
การใช้งาน
western blot
Anti-MAP3K8 antibody produced in rabbit, affinity isolated antibody,
ความสามารถในการตอบสนองของสายพันธุ์
human, mouse, rat
การใช้งาน
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot
Proteins
Product Number
คำอธิบาย
สายพันธุ์
Cot1 Protein, active, 10 µg, Active, N-terminal 6His-tagged recombinant human Cot1, amino acids 30-397. For use in Kinase Assays.,
สายพันธุ์
human