773069

Fmoc-N-Me-Cys(Trt)-OH

97% (HPLC)

• 別名: N-α-Fmoc-N-α-methyl-S-trityl-L-cysteine
• 実験式（ヒル表記法）: C₃₈H₃₃NO₄S
• CAS番号: 944797-51-7
• 分子量: 599.74
• MDL番号: MFCD11973909
• UNSPSCコード: 12352209
• NACRES: NA.26

特性

• 品質水準: 100
• アッセイ: 97% (HPLC)
• フォーム: powder or crystals
• 光学活性: [α]22/D -25.0°, c = 0.5% in dichloromethane
• 反応適合性: reaction type: Fmoc solid-phase peptide synthesis
• mp: 234-239 °C
• アプリケーション: peptide synthesis
• 官能基: Fmoc
• 保管温度: 2-8°C
• SMILES記法: S(C[C@H](N(C)C(=O)OCC4c5c(cccc5)c6c4cccc6)C(=O)O)C(c3ccccc3)(c2ccccc2)c1ccccc1
• InChI: 1S/C38H33NO4S/c1-39(37(42)43-25-34-32-23-13-11-21-30(32)31-22-12-14-24-33(31)34)35(36(40)41)26-44-38(27-15-5-2-6-16-27,28-17-7-3-8-18-28)29-19-9-4-10-20-29/h2-24,34-35H,25-26H2,1H3,(H,40,41)/t35-/m0/s1
• InChI Key: RAKOPMQMPUNRGI-DHUJRADRSA-N

詳細

アプリケーション

Fmoc-N-Me-Cys(Trt)-OH is a Fmoc-protected derivative of N-methyl cysteine used as a building block to prepare peptide thioesters under acidic conditions. The residue attached to the amino group of N-methylcysteine can migrate to the cysteinyl thiol group, resulting in the formation of a peptide thioester. The introduction of this Fmoc-protected derivative is best achieved using HATU as a coupling reagent in the presence of DIPEA (N, N-Diisopropylethylamine).
It can also be used to prepare Fmoc-N-Me-Cys(Trt)-OAllyl intermediate for the solid-phase synthesis of dithiol Triostin A.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable