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詳細
NanoFabTx™ Microfluidic - micro device kit is designed to work with the NanoFabTx™ - micro reagent kits like (Cat. No. 912212) for the synthesis of 10-30 μm particles. The device kit includes a comprehensive protocol, pre-assembled microfluidic chip manifold, tubing, and required accessories and is compatible with either the Dolomite microfluidics system or a standard syringe pump (compatible microfluidics system or syringe pump required separately).
アプリケーション
NanoFabTx™ Microfluidic - micro device kit in combination with the NanoFabTx™ - micro reagent kits (Cat. No. 912212) can be used to create drug-encapsulating polymeric microparticles 10-30 μm in size. Because of the adjustable flow rate, small reaction window, and adjustable concentrations, microfluidic-based synthesis is a powerful tool for fabricating size-controlled particles to encapsulate drugs, small molecules, mRNA, DNA, and proteins. The chip geometries and flow parameters enable facile, scalable synthesis of monodispersed particles with consistent size and drug loading to facilitate rapid formulation screening.
特徴および利点
- Simplifies polymer chemistry of microfluidic formulation development for enhancing drug bioavailability
- Accelerates optimization of drug encapsulation and loading efficiency in microparticles
- Provides step-by-step microfluidic-based protocols developed and tested by our formulation scientists
- Minimizes waste of expensive reagents
法的情報
NANOFABTX is a trademark of Sigma-Aldrich Co. LLC
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最新バージョンのいずれかを選択してください：
Andrew Gdowski et al.
Journal of nanobiotechnology, 16(1), 12-12 (2018-02-13)
The process of optimization and fabrication of nanoparticle synthesis for preclinical studies can be challenging and time consuming. Traditional small scale laboratory synthesis techniques suffer from batch to batch variability. Additionally, the parameters used in the original formulation must be
Samar Damiati et al.
Genes, 9(2) (2018-02-22)
Microfluidic devices present unique advantages for the development of efficient drug carrier particles, cell-free protein synthesis systems, and rapid techniques for direct drug screening. Compared to bulk methods, by efficiently controlling the geometries of the fabricated chip and the flow
Xuanyu Li et al.
Advanced drug delivery reviews, 128, 101-114 (2017-12-27)
Microfluidic chips allow the rapid production of a library of nanoparticles (NPs) with distinct properties by changing the precursors and the flow rates, significantly decreasing the time for screening optimal formulation as carriers for drug delivery compared to conventional methods.
資料
NanoFabTx™ platform accelerates drug development with ready-to-use formulations and microfluidic devices for particle synthesis.
NanoFabTx™キットは、ナノ粒子・リポソームドラッグデリバリー製剤の迅速かつ十分に制御された合成のために最適化されています。薬物放出挙動が制御された、さまざまな治療薬化合物のカプセル化を行うことができます。
NanoFabTx™DDS製剤プラットフォームは、マイクロ粒子、ナノ粒子またはリポソーム製剤を容易に合成可能なキットです。NanoAssemblr®装置を用いたナノ製剤化事例をご紹介します。
NanoFabTX kits enable precise drug delivery with lipid nanoparticles and liposomes for mRNA and nucleic acids.
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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