QBD10773

dPEG^®₂₄-biotin acid

>95% (HPLC)

• 別名: Biotin-PEG-acid, Biotin-PEG₂₄-COOH, PEG₁₀₀₀ biotin acid, PEG₂₄-biotin acid
• 実験式（ヒル表記法）: C₆₁H₁₁₇N₃O₂₈S
• 分子量: 1372.65
• MDL番号: MFCD26793761
• UNSPSCコード: 12352106
• NACRES: NA.22

特性

• アッセイ: >95% (HPLC)
• フォーム: solid or viscous liquid
• 反応適合性: reaction type: Biotinylations; reaction type: Pegylations
• ポリマー構造: shape: linear; functionality: monofunctional
• 輸送温度: ambient
• 保管温度: −20°C
• SMILES記法: S1C(C2NC(=O)NC2C1)CCCCC(=O)NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(=O)O
• InChI: 1S/C61H117N3O28S/c65-58(4-2-1-3-57-60-56(55-93-57)63-61(68)64-60)62-6-8-70-10-12-72-14-16-74-18-20-76-22-24-78-26-28-80-30-32-82-34-36-84-38-40-86-42-44-88-46-48-90-50-52-92-54-53-91-51-49-89-47-45-87-43-41-85-39-37-83-35-33-81-31-29-79-27-25-77-23-21-75-

詳細

特徴および利点

dPEG₂₄ biotin acid consists of a biotin molecule conjugated to a single molecular weight polyethylene glycol chain of discrete length (dPEG). The dPEG chain is 76 atoms (90.1 Å) long. The distal end of the dPEG chain terminates with a propionic acid group. The terminal acid is available for direct conjugation to free amines or functionalization as an active ester. Amphiphilic dPEG₂₄ biotin acid can be dissolved both in water or aqueous buffer and in organic solvent. It does not cause aggregation or precipitation of biomolecules. Using 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC) chemistry, dPEG₂₄ biotin acid can be coupled directly to free primary amines in aqueous media. These free amines can be on a protein, peptide, or the treated surface of a nanoparticle. Moreover, the acid moiety can be functionalized with other reactive groups for coupling directly to surfaces such as glass, gold, or magnetic nanoparticles. The linker length of dPEG₂₄ biotin acid is much longer than the linker lengths of LC-biotin and of LC-LC-biotin and is a monodisperse equivalent of a PEG₁₀₀₀. The performance characteristics of dPEG₂₄-biotin acid are quite superior to both LC-biotin and LC-LC-biotin.

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法的情報

Products Protected under U.S. Patent #s 7,888,536 & 8,637,711 and European Patent #s 1,594,440 & 2,750,681

dPEG is a registered trademark of Quanta BioDesign

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable