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powder
包装
pkg of 1 × 25 mg (860514P-25mg)
pkg of 1 × 5 mg (860514P-5mg)
メーカー／製品名
Avanti Research™ - A Croda Brand 860514P
脂質タイプ
sphingolipids
輸送温度
dry ice
保管温度
−20°C
SMILES記法
OC[C@]([H])(NC(CCCCCCCCCCCCC)=O)[C@]([H])(O)/C=C/CCCCCCCCCCCCC
InChI
1S/C32H63NO3/c1-3-5-7-9-11-13-15-16-18-19-21-23-25-27-31(35)30(29-34)33-32(36)28-26-24-22-20-17-14-12-10-8-6-4-2/h25,27,30-31,34-35H,3-24,26,28-29H2,1-2H3,(H,33,36)/b27-25+/t30-,31+/m0/s1
InChI Key
ZKRPGPZHULJLKJ-JHRQRACZSA-N
詳細
Ceramide synthesis is majorly driven by de novo pathway involving the palmitoyl-CoA and L-serine, and also by salvage pathway via recycling of complex sphingolipids. The ceramide transporter, Cert mediates the transfer of C14 from smooth endoplasmic reticulum to Golgi. Ceramide synthase CerS6 enzyme is involved in the synthesis of C14 ceramide.
アプリケーション
C14 Ceramide (d18:1/14:0) is suitable for use
- as a standard in high-performance liquid chromatography/tandem mass spectrometry (LC/MS2) for ceramide quantification from muscel biopsies
- in lipid monolayer preparation for biophysical studies
- in the morphological and dimensional evaluation studies
生物化学的／生理学的作用
Ceramides regulate biological processes including proliferation, differentiation and apoptosis. In the cystic fibrosis patients, elevated levels of C14 ceramide is observed. It is also a potential biomarker for hepatic steatosis (HS) and C14 ceramide levels correlate with the aspartate aminotransferase (AST) / alanine transaminase (ALT) ratio. Tumor necrosis factor α (TNFα) mediates increase in the C14 levels. Fumonisin B1 prevents the C14 accumulation.
包装
5 mL Amber Glass Screw Cap Vial (860514P-25mg)
5 mL Amber Glass Screw Cap Vial (860514P-5mg)
法的情報
Avanti Research is a trademark of Avanti Polar Lipids, LLC
よく一緒に購入される製品
製品番号
詳細
価格
保管分類コード
11 - Combustible Solids
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
860514P-BULK:
860514P-VAR:
860514P-5MG:
860514P-25MG:
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Biochemistry of very-long-chain and long-chain ceramides in cystic fibrosis and other diseases: The importance of side chain
Garic D, et al.
Progress in Lipid Research (2019)
Ceramide N-acyl chain length: a determinant of bidimensional transitions, condensed domain morphology, and interfacial thickness
Dupuy F, et al.
Langmuir, 27(7), 3783-3791 (2011)
Association between Plasmatic Ceramides Profile and AST/ALT Ratio: C14: 0 Ceramide as Predictor of Hepatic Steatosis in Adolescents Independently of Obesity
Maldonado-Hernandez J, et al.
Canadian journal of gastroenterology & hepatology, 2017 (2017)
Tumor necrosis factor-alpha(TNFalpha)-induced ceramide generation via ceramide synthases regulates loss of focal adhesion kinase (FAK) and programmed cell death
Hernandez-Corbacho M, et al.
The Journal of Biological Chemistry, 290(42), 25356-25373 (2015)
Ceramide effects in the bicelle structure
Barbosa-Barros L, et al.
Colloids and Surfaces. A, Physicochemical and Engineering Aspects, 317(1-3), 576-584 (2008)
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