890899C

DODMA

Avanti Research^™ - A Croda Brand

• 別名: 1,2-Dioleyloxy-3-dimethylaminopropane
• 実験式（ヒル表記法）: C₄₁H₈₁NO₂
• CAS番号: 104162-47-2
• 分子量: 620.09
• UNSPSCコード: 12352211
• NACRES: NA.25

特性

• アッセイ: >99% (TLC)
• 形状: chloroform solution
• 包装: pkg of 1 × 4 mL (890899C-100MG); pkg of 5 × 4 mL (890899C-500MG)
• メーカー／製品名: Avanti Research^™ - A Croda Brand
• 濃度: 25 mg/mL in chloroform
• アプリケーション: advanced drug delivery
• 脂質タイプ: cationic lipids; transfection
• 輸送温度: dry ice
• 保管温度: −20°C
• SMILES記法: CN(C)CC(OCCCCCCCC/C=C\CCCCCCCC)COCCCCCCCC/C=C\CCCCCCCC
• InChI: 1S/C41H81NO2/c1-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-35-37-43-40-41(39-42(3)4)44-38-36-34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-2/h19-22,41H,5-18,23-40H2,1-4H3
• InChI Key: GLGLUQVVDHRLQK-UHFFFAOYSA-N

詳細

詳細

DODMA (1,2-dioleyloxy-3-dimethylaminopropane) is an ionizable cationic lipid. DODMA possesses one double bond in each hydrocarbon tail with tertiary amine group and has a pKa of 7.0.

アプリケーション

DODMA is suitable for use in the preparation of lipid nanoparticles (LNPs).

生物化学的／生理学的作用

DODMA (1,2-dioleyloxy-3-dimethylaminopropane) is used in the preparation of cationic liposomes and lipid nanoparticles (LNPs). LNPs with DODMA has low or neutral zeta potential. DODMA is efficient in encapsulating nucleic acid during synthesis by reducing the physiological pH. DODMA is implicated in gene therapy.

包装

5 mL Clear Glass Sealed Ampule (890899C-100MG)
5 × 5 mL Clear Glass Sealed Ampule (890899C-500MG)

法的情報

Avanti Research is a trademark of Avanti Polar Lipids, LLC

安全性情報

• ピクトグラム: GHS06,GHS08
• シグナルワード: Danger
• 危険有害性情報: H302,H315,H319,H331,H336,H351,H361d,H372
• 注意書き: P201 - P260 - P264 - P280 - P304 + P340 + P311 - P403 + P233
• 危険有害性の分類: Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3
• ターゲットの組織: Central nervous system
• 保管分類コード: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable