233165

Clioquinol

A metal ion chelator that crosses the blood brain barrier and acts as a neurotoxic antibiotic.

• 別名: Clioquinol, 5-Chloro-7-iodo-8-hydroxyquinoline
• 実験式（ヒル表記法）: C₉H₅ClINO
• CAS番号: 130-26-7
• 分子量: 305.50
• MDL番号: MFCD00006787
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥95% (HPLC)
• フォーム: solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; protect from light
• 溶解性: ethanol: 1 mg/mL; methanol: 1.5 mg/mL; DMSO: 20 mg/mL
• 輸送温度: ambient
• 保管温度: −20°C
• SMILES記法: Ic1c(c2ncccc2c(c1)Cl)O
• InChI: 1S/C9H5ClINO/c10-6-4-7(11)9(13)8-5(6)2-1-3-12-8/h1-4,13H
• InChI Key: QCDFBFJGMNKBDO-UHFFFAOYSA-N

詳細

詳細

A metal ion chelator that crosses the blood brain barrier and acts as a neurotoxic antibiotic. Reported to dissolve senile plaques and reduce amyloid’s ability to clump together, apparently by trapping the Cu²⁺ and Zn²⁺ that stud these deposits. Shown to increase distal dominant axonopathy in animal models.

A metal ion chelator that crosses the blood-brain barrier and acts as a neurotoxic antibiotic. Reported to dissolve senile plaques and reduce amyloid′s ability to clump together, apparently by trapping the Cu²⁺ and Zn²⁺ that reduces the build-up of these deposits. Exhibits greater affinity for Cu²⁺ and Zn²⁺ than for Ca²⁺ and Mg²⁺. Shown to induce distal dominant axonopathy in animal models. Clioquinol treatment has been shown to be beneficial in a mouse model of Alzheimer′s disease.

生物化学的／生理学的作用

Cell permeable: no

Primary Target
Metal ion chelator

Product does not compete with ATP.

Reversible: no

包装

Packaged under inert gas

警告

Toxicity: Toxic & Carcinogenic / Teratogenic (G)

再構成

Following reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 3 months at -20°C.

その他情報

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Melov, S. 2002. Trends Neurosci.25, 121.
Regland, B., et al. 2001. Dement. Geriatr. Cogn. Disord.12, 408.
Helmuth, L., et al. 2000. Science290, 1273.
Tateishi, J., et al. 2000. Neuropathology20, Suppl: S20-4.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• ピクトグラム: GHS06
• シグナルワード: Danger
• 危険有害性情報: H301,H315,H317,H319
• 注意書き: P261 - P264 - P280 - P301 + P310 - P302 + P352 - P305 + P351 + P338
• 危険有害性の分類: Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1
• 保管分類コード: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3