251400

D609, Potassium Salt

Selective inhibitor of phosphatidylcholine (PC)-specific phospholipase C (K_i = 5-10 µM).

• 別名: D609, Potassium Salt, Tricyclodecan-9-yl-xanthogenate, K
• 実験式（ヒル表記法）: C₁₁H₁₅OS₂ · K
• CAS番号: 83373-60-8
• 分子量: 266.46
• MDL番号: MFCD00171401
• UNSPSCコード: 41106500
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• 形状: powder
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; desiccated (hygroscopic)
• 色: off-white
• 溶解性: DMSO: 25 mg/mL; water: 25 mg/mL
• 輸送温度: ambient
• 保管温度: 2-8°C
• InChI: 1S/C11H16OS2.K/c13-11(14)12-10-5-6-4-9(10)8-3-1-2-7(6)8;/h6-10H,1-5H2,(H,13,14);
• InChI Key: YFUFHKMDCZBHMY-UHFFFAOYSA-N

詳細

詳細

Selective inhibitor of phosphatidylcholine (PC)-specific phospholipase C (K_i = 5-10 µM). Does not inhibit phosphatidylinositol-specific phospholipase C, phospholipase A, or phospholipase D. Also reported to inhibit LPS-stimulated ERK activation via its inhibitory effect on PLC. Inhibits angiogenesis by preventing the synthesis of basement membrane.

Selective inhibitor of phosphatidylcholine-specific phospholipase C (PC-PLC) (Bacillus cereus, K_i = 5-10 µM). Does not inhibit (up to 50 µM) phosphatidylinositol-specific phospholipase C, phospholipase A₂, and phospholipase D. Inhibitor of the sphingomyelinase activity. Also inhibits angiogenesis by preventing the synthesis of basement membrane (BM).

生物化学的／生理学的作用

Cell permeable: no

Primary Target
pc-specificphopholipase c

Product does not compete with ATP.

Reversible: no

Target K_i: 5-10 µM against phosphatidylcholine (PC)-specific phospholipase C

警告

Toxicity: Standard Handling (A)

調製ノート

tissue culture media should be at neutral pH, since product is active only at or slightly below pH 7.0. The compound is inactive at pH 7.4 and above, and it is hydrolyzed below pH 6.0. HEPES buffer should not be used as it renders D609 toxic.

再構成

Material is very labile once in solution (1.5 day half-life in tissue culture medium).

その他情報

Monick, M.M., et al. 1999. J. Immunol. 162, 3005.
Lozanski, G., et al. 1997. Biochem. J.328, 271.
Maragoudakis, M.E., et al. 1993. Kidney Int. 43, 147.
Doppler, C., et al. 1992. AIDS Res. Human Retroviruses8, 245.
Schutze, S., et al. 1992. Cell71, 765.
Sauer, G., et al. 1990. Cancer Lett.53, 97.
Muller-Decker, K. 1989. Biochem. Biophys. Res. Commun.162, 198.
Amtmann, E., et al. 1987. Biochem. Pharmacol.36, 1545.
Sauer, G., et al. 1984. Proc. Natl. Acad. Sci. USA81, 3263.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable