344220

Formyl Peptide Receptor-Like 1 Antagonist, WRW⁴

The Formyl Peptide Receptor-Like 1 Antagonist, WRW⁴ controls the biological activity of Formyl Peptide Receptor-Like 1.

• 別名: Formyl Peptide Receptor-Like 1 Antagonist, WRW⁴, H₂N-WRWWWW-CONH₂, FPRL1 Antagonist, WRW⁴
• 実験式（ヒル表記法）: C₆₁H₆₅N₁₅O₆
• 分子量: 1104.27
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥95% (HPLC)
• 形状: lyophilized solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; desiccated (hygroscopic)
• 色: white
• 溶解性: DMSO: 5 mg/mL
• 輸送温度: ambient
• 保管温度: 2-8°C

詳細

詳細

A Trp-rich hexapeptide that acts as a potent and specific antagonist of Formyl Peptide Receptor-Like 1 (FPRL1)-mediated signaling. Shown to bind to FPRL1 and interfere with ligand-receptor interaction {IC₅₀ = 230 nM for FPRL1 Agonist, WKYMVm (Cat. No. 344216)}. Completely blocks ligand-mediated [Ca²⁺]_i increase, ERK activation, and chemotactic migration of FPRL1-expressing RBL-2H3 cells at a concentration of 10 µM. Also inhibits Aβ₄₂ peptide-induced superoxide generation and prevents its internalization in human macrophages.

A Trp-rich hexapeptide that acts as a potent and specific antagonist of Formyl Peptide Receptor-Like 1 (FPRL1)-mediated signaling. Shown to bind to FPRL1 and interfere with the ligand-receptor interaction {IC₅₀ = 230 nM for FPRL1 Agonist, WKYMVm (Cat. No. 344216)}. Completely blocks the ligand activated [Ca²⁺]_i increase, ERK activation and chemotactic migration of FPRL1-expressing RBL-2H3 cells at 10 µM. Further, inhibits Aβ₄₂ peptide-induced superoxide generation and prevents its internalization in human macrophages.

生物化学的／生理学的作用

Cell permeable: no

Primary Target
Formyl Peptide Receptor-Like 1 (FPRL1)

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 230 nM for FPRL1 Agonist

包装

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

シーケンス

H-Trp-Arg-Trp-Trp-Trp-Trp-CONH₂

物理的形状

Supplied as a trifluoroacetate salt.

再構成

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

その他情報

Bae, Y.S., et al. 2004. J. Immunol.173, 607.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable