345733-M

Ganglioside GM₃, Monosialo, Ammonium Salt, Bovine Milk

Contains mainly N-acetylneuraminic acid.

• 別名: Ganglioside GM₃, Monosialo, Ammonium Salt, Bovine Milk, Neu5Acα2,3Galβ1,4Glcβ1,1 Ceramide, NH₄
• 実験式（ヒル表記法）: C₆₄H₁₁₈N₂O₂₁ · NH₄
• 分子量: 1269.66
• UNSPSCコード: 12352211

特性

• 品質水準: 100
• アッセイ: ≥98% (TLC)
• フォーム: solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze
• 色: white
• 溶解性: chloroform/methanol (2:1): soluble
• 保管温度: −20°C

詳細

詳細

Contains mainly N-acetylneuraminic acid. GM₃ and its derivatives play important roles in immunoregulation and in biosynthesis and metabolism of higher gangliosides. GM₃ is reported to inhibit EGF-receptor tyrosine kinase activity in whole cells and plasma membranes, and in detergent micelles. Inhibits protein kinase C activity in both cytosolic and total particulate fractions (IC₅₀ = 100 - 115 µM). Induces the down-modulation of CD4 molecules. Useful as a substrate for neuraminidases. Binds EGF and FGF.

Contains mainly N-acetylneuraminic acid. GM₃ and its derivatives play important roles in immunoregulation and in the biosynthesis and metabolism of higher gangliosides. Inhibits protein kinase C activity in both cytosolic and total particulate fractions(IC₅₀ = 100-115 µM). Induces the down-modulation of CD4 molecules. Useful as a substrate for neuraminidases. Binds EGF and FGF.

M.W. 1198.5 (based on stearoyl - 18:0).

生物化学的／生理学的作用

Primary Target
Protein kinase C, EGF-receptor tyrosine kinase

Target IC₅₀: 100 - 115 µM inhibiting protein kinase C activity in both cytosolic and total particulate fractions

警告

Toxicity: Irritant (B)

その他情報

Katoh, N. 1995. Life Sci. 56, 157.
Sorice, M., et al. 1995. Scand. J. Immunol. 41, 148.
Kadowaki, H., and Grant, M.A. 1994. J. Biol. Chem. 269, 14931.
Muthing, J., et al. 1994. J. Biochem. (Tokyo) 116, 64.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable