420413

Polymyxin B Sulfate, Sterile-Filtered Aqueous Solution, Cell Culture Tested

An antibiotic that inhibits phospholipid sensitive Ca2+-dependent protein kinase.

• 別名: Polymyxin B Sulfate, Sterile-Filtered Aqueous Solution, Cell Culture Tested, Aerosporin, Sterile-Filtered Aqueous Solution, Cell Culture Tested
• CAS番号: 1405-20-5
• MDL番号: MFCD00131991
• UNSPSCコード: 12352200

特性

• 品質水準: 100
• 形状: liquid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze
• 色: clear
• 輸送温度: wet ice
• 保管温度: −20°C
• InChI: 1S/C48H82N16O13.H2O4S/c1-27(2)24-37-47(76)59-32(11-19-52)41(70)56-31(10-18-51)43(72)61-35(14-22-65)39(68)54-21-13-34(45(74)57-33(12-20-53)44(73)64-38(48(77)63-37)25-28-6-4-3-5-7-28)60-42(71)30(9-17-50)58-46(75)36(15-23-66)62-40(69)29(8-16-49)55-26-67;1-5(2,3)4/h3-7,26-27,29-38,65-66H,8-25,49-53H2,1-2H3,(H,54,68)(H,55,67)(H,56,70)(H,57,74)(H,58,75)(H,59,76)(H,60,71)(H,61,72)(H,62,69)(H,63,77)(H,64,73);(H2,1,2,3,4)
• InChI Key: HNDFYNOVSOOGDU-UHFFFAOYSA-N

詳細

詳細

An antibiotic that inhibits phospholipid sensitive Ca²⁺-dependent protein kinase. Mixture of polymyxin B₁ sulfate and polymyxin B₂ sulfate. Binds to cell wall and makes it more permeable, causing fluid uptake. Effective against Gram-negative bacteria.

生物化学的／生理学的作用

≥7500 units/mg

警告

Toxicity: Harmful (C)

物理的形状

Supplied at 50 mg/ml in H₂O.

再構成

Following initial thaw, aliquot and freeze (-20°C).

その他情報

Lucas, M., et al. 1994. Biochem. Pharmacol.47, 667.
Ngezahayo, A. and Kolb, H.A. 1993. Pflugers Arch.422, 413.
Kubo, M. and Okada, Y. 1992. J. Physiol.456, 351.
Strasser, R.H., et al. 1992. Circ. Res.70, 1304.
Hegemann, L., et al. 1991. Eur. J. Pharmacol.207, 17.
Inaba, H. and Finkins, J.P. 1991. Am. J. Physiol.261, R26.
Marra, M.N., et al. 1990. J. Immunol.144, 662.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• ピクトグラム: GHS07
• シグナルワード: Warning
• 危険有害性情報: H302
• 注意書き: P264 - P270 - P301 + P312 - P501
• 危険有害性の分類: Acute Tox. 4 Oral
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable