443300

MCI-186

A free radical scavenger and antioxidant that reduces post-ischemic brain injury.

• 別名: MCI-186, 3-Methyl-1-phenyl-2-pyrazolin-5-one, PMP, Edaravone
• 実験式（ヒル表記法）: C₁₀H₁₀N₂O
• CAS番号: 89-25-8
• 分子量: 174.20
• MDL番号: MFCD00003138
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• 形状: solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; protect from light
• 色: cream
• 溶解性: DMSO: 100 mg/mL
• 輸送温度: ambient
• 保管温度: 2-8°C
• InChI: 1S/C10H10N2O/c1-8-7-10(13)12(11-8)9-5-3-2-4-6-9/h2-6H,7H2,1H3
• InChI Key: QELUYTUMUWHWMC-UHFFFAOYSA-N

詳細

詳細

A free radical scavenger and antioxidant that reduces post-ischemic brain injury. Inhibits iron-dependent peroxidation in rat brain homogenates (IC₅₀ = 15 µM). Inhibits mitochondrial permeability transition pore.

A free radical scavenger and antioxidant that reduces post-ischemie brain injury. Inhibits iron-dependent peroxidation in rat brain homogenates (IC₅₀ = 15 µM). Inhibits mitochondrial permeability transition pore.

生物化学的／生理学的作用

Cell permeable: no

Primary Target
A free radical scavenger and antioxidant

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 15 µM inhibiting iron-dependent peroxidation in rat brain homogenates

包装

Packaged under inert gas

警告

Toxicity: Harmful (C)

再構成

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

その他情報

Katare, R. G., et al. 2003. Am. J. Physiol.285, H2171.
Kawai, H., et al. 1997. J. Pharmacol. Exp. Ther. 281, 921.
Yamamoto, Y., et al. 1996. Redox. Report 2, 333.
Watanabe, T., et al. 1994. J. Pharmacol. Exp. Ther. 268, 1597.
Nishi, H., et al. 1989. Stroke 20, 1236.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• ピクトグラム: GHS07
• シグナルワード: Warning
• 危険有害性情報: H302,H319
• 注意書き: P264 - P280 - P301 + P312 - P305 + P351 + P338 - P337 + P313 - P501
• 危険有害性の分類: Acute Tox. 4 Oral - Eye Irrit. 2
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 1