506106

p21-Activated Kinase Inhibitor III, IPA-3

The p21-Activated Kinase Inhibitor III, IPA-3, also referenced under CAS 42521-82-4, controls the biological activity of p21-Activated Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• 別名: p21-Activated Kinase Inhibitor III, IPA-3, 2,2ʹ-Dihydroxy-1,1ʹ-dinaphthyldisulfide, PAK Inhibitor III
• 実験式（ヒル表記法）: C₂₀H₁₄O₂S₂
• CAS番号: 42521-82-4
• 分子量: 350.45
• MDL番号: MFCD00388917
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥97% (HPLC)
• フォーム: solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; protect from light
• 色: yellow
• 溶解性: DMSO: 10 mg/mL; ethanol: 2 mg/mL
• 輸送温度: wet ice
• 保管温度: −20°C
• SMILES記法: S(Sc3c4c(ccc3O)cccc4)c1c2c(ccc1O)cccc2
• InChI: 1S/C20H14O2S2/c21-17-11-9-13-5-1-3-7-15(13)19(17)23-24-20-16-8-4-2-6-14(16)10-12-18(20)22/h1-12,21-22H
• InChI Key: RFAXLXKIAKIUDT-UHFFFAOYSA-N

詳細

詳細

A cell-permeable symmetrical disulfide allosteric inhibitor that selectively targets the autoregulatory domain of group I, but not group II, PAKs (p21-activated kinases) and prevents the activation of PAK1/2/3 (% inhibition= 95, 70, and 60, respectively, with 10 µM inhibitor; IC₅₀ = 2.5 µM for PAK1). Specificity test shows ≥ 50% inhibition, in the presence of 10 µM ATP and inhibitor, against 9 of 214 non-PAK human kinases. Shown to effectively suppress both basal and PDGF-induced PAK activation at 30 µM in mouse embryonic fibroblasts. IPA-3 does not inhibit the enzymatic activity of preactivated PAKs and reduction of the intramolecular disulfide bond of IPA-3 by DTT renders it inactive.

包装

Packaged under inert gas

警告

Toxicity: Irritant (B)

その他情報

Deacon, S.W., et al. 2008. Chem. Biol.15, 322.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• ピクトグラム: GHS05,GHS09
• シグナルワード: Danger
• 危険有害性情報: H318,H410
• 注意書き: P273 - P280 - P305 + P351 + P338 - P391 - P501
• 危険有害性の分類: Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable