428020

Latrunculin B

from Latrunculia magnifica, ≥95% (HPLC), solid, actin polymerization inhibitor, Calbiochem^®

• 別名: Latrunculin B, Latrunculia magnifica
• 実験式（ヒル表記法）: C₂₀H₂₉NO₅S
• CAS番号: 76343-94-7
• 分子量: 395.51
• MDL番号: MFCD00270879
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• 製品名: Latrunculin B, Latrunculia magnifica, Latrunculin B, CAS 76343-94-7, is a unique marine toxin that inhibits actin polymerization and disrupts microfilament organization. It is 10 to 100-fold more potent than cytochalasins.
• 品質水準: 100
• 詳細: Merck USA index - 14, 5378
• アッセイ: ≥95% (HPLC)
• フォーム: solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze
• 色: off-white to yellow
• 溶解性: DMSO: 25 mg/mL; ethanol: 25 mg/mL; methanol: 50 mg/mL
• 輸送温度: ambient
• 保管温度: −20°C
• SMILES記法: S1C[C@H](NC1=O)[C@@]2(O[C@H]3C[C@@H](OC(=O)\C=C(/CC\C=C/[C@H](CC3)C)\C)C2)O
• InChI: 1S/C20H29NO5S/c1-13-5-3-4-6-14(2)9-18(22)25-16-10-15(8-7-13)26-20(24,11-16)17-12-27-19(23)21-17/h3,5,9,13,15-17,24H,4,6-8,10-12H2,1-2H3,(H,21,23)/b5-3-,14-9-/t13-,15-,16-,17+,20-/m1/s1
• InChI Key: NSHPHXHGRHSMIK-JRIKCGFMSA-N

詳細

詳細

A structurally unique marine toxin. Inhibits actin polymerization in vitro and disrupts microfilament organization as well as microfilament-mediated processes. 10 to 100-fold more potent than cytochalasins.

生物化学的／生理学的作用

Cell permeable: no

Primary Target
Actin polymerization

Product does not compete with ATP.

Reversible: no

警告

Toxicity: Harmful (C)

その他情報

Spector, I., et al. 1989. Cell Motil. Cytoskeleton13, 127.
de Oliveira, C.A., and Mantovani, B. 1988. Life Sci.43, 1825.
Coue, M., et al. 1987. FEBS Lett.213, 316.
Spector, I., et al. 1983. Science219, 493.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable