203391

(-)-Blebbistatin

≥98% (HPLC), solid, ATPase inhibitor, Calbiochem^®

• 別名: (-)-Blebbistatin
• 実験式（ヒル表記法）: C₁₈H₁₆N₂O₂
• CAS番号: 856925-71-8
• 分子量: 292.33
• MDL番号: MFCD08460907
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• product name: (-)-Blebbistatin, The active enantiomer of (±)-Blebbistatin that accounts for the inhibitory activity towards ATPase and myosin II-dependent cellular processes.
• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• 形状: solid
• 有効性: 2 μM IC₅₀
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; protect from light
• 色: yellow
• 溶解性: methanol: 1.5 mg/mL; 100% DMSO: 100 mg/mL; 90% DMSO: 75 mg/mL
• 輸送温度: wet ice
• 保管温度: −20°C
• InChI: 1S/C18H16N2O2/c1-12-7-8-15-14(11-12)16(21)18(22)9-10-20(17(18)19-15)13-5-3-2-4-6-13/h2-8,11,22H,9-10H2,1H3/t18-/m1/s1
• InChI Key: LZAXPYOBKSJSEX-GOSISDBHSA-N

詳細

詳細

The active enantiomer of (±)-Blebbistatin (Cat. No. 203390) that accounts for the inhibitory activity towards ATPase (IC₅₀ = ~2 µM) and myosin II-dependent cellular processes. Also reported to potently inhibit the actomyosin ATPase activities of expressed smooth muscle myosin IIA (SMA) and smooth muscle myosin IIB (SMB) smooth muscle myosin II heavy-chain isoforms (IC₅₀ ~3 µM).

The active enantiomer of (±)-Blebbistatin (Cat. No. 203390) that accounts for the inhibitory activity toward ATPase (IC₅₀ ~2 µM) and myosin II-dependent cellular processes. Also reported to potently inhibit the actomyosin ATPase activities of expressed smooth muscle myosin IIA (SMA) and smooth muscle myosin IIB (SMB) smooth muscle myosin II heavy-chain isoforms (IC₅₀ ~3 µM).

生物化学的／生理学的作用

Cell permeable: yes

Product does not compete with ATP.

Reversible: yes

包装

Packaged under inert gas

警告

Toxicity: Harmful & Carcinogenic / Teratogenic (E)

再構成

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month in 90% DMSO or methanol (-20°C). Stock solutions in 100% DMSO are unstable; reconstitute just prior to use.

その他情報

Eddinger, T.J. et al. 2007. J. Pharmacol. Exp. Ther.320, 865.
Shu, S., et al. 2005. Proc. Natl. Acad. Sci. USA102, 1472.
Kovacs, M., et al. 2004. J. Biol. Chem.279, 35557.
Straight, A.F., et al. 2003. Science299, 1743.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3