574714

BAY 61-3606

≥97% (HPLC), solid, Syk inhibitor, Calbiochem^®

• 別名: Syk Inhibitor IV, BAY 61-3606, 2-(7-(3,4-Dimethoxyphenyl)-imidazo[1,2-c]pyrimidin-5-ylamino)-nicotinamide, HCl, BAY 61-3606
• 実験式（ヒル表記法）: C₂₀H₁₈N₆O₃ · xHCl · yH₂O
• CAS番号: 732983-37-8
• 分子量: 390.40 (anhydrous free base basis)
• MDL番号: MFCD18641826
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• 製品名: Syk Inhibitor IV, BAY 61-3606, The Syk Inhibitor IV, BAY 61-3606, also referenced under CAS 732938-37-8, controls the biological activity of Syk. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
• 品質水準: 100
• アッセイ: ≥97% (HPLC)
• フォーム: solid
• 有効性: 10 nM IC₅₀
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; desiccated (hygroscopic); protect from light
• 色: yellow
• 溶解性: DMSO: 10 mg/mL; water: 20 mg/mL
• 輸送温度: ambient
• 保管温度: 2-8°C
• SMILES記法: [n]21c(ncc2)cc(nc1Nc4ncccc4C(=O)N)c3cc(c(cc3)OC)OC
• InChI: 1S/C20H18N6O3/c1-28-15-6-5-12(10-16(15)29-2)14-11-17-22-8-9-26(17)20(24-14)25-19-13(18(21)27)4-3-7-23-19/h3-11H,1-2H3,(H2,21,27)(H,23,24,25)
• InChI Key: JWQOJVOKBAAAAR-UHFFFAOYSA-N

詳細

詳細

A cell-permeable imidazopyrimidine compound that acts a potent, ATP-competitive, reversible, and highly selective inhibitor of Syk tyrosine kinase activity (IC₅₀ = 10 nM) with no inhibitory effect against Btk, Fyn, Itk, Lyn, and Src even at concentrations as high as 4.7 µM. Shown to inhibit Syk-mediated cellular functions in vitro and exhibit good oral bioavailability and in vivo effacacy in the treatment of various allgery and asthma conditions in rat models.

生物化学的／生理学的作用

Cell permeable: yes

Primary Target
Syk

Product competes with ATP.

Reversible: yes

包装

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

再構成

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

その他情報

Yamamoto, N., et al. 2003. J. Pharm. Exp. Ther.306, 1174.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 2
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable