574713

Syk Inhibitor III

The Syk Inhibitor III, also referenced under CAS 1485-00-3, controls the biological activity of Syk. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• 別名: Syk Inhibitor III, 3,4-Methylenedioxy-β-nitrostyrene
• 実験式（ヒル表記法）: C₉H₇NO₄
• CAS番号: 1485-00-3
• 分子量: 193.16
• MDL番号: MFCD00014575
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (GC)
• フォーム: solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; protect from light
• 色: yellow to brown
• 溶解性: DMSO: 25 mg/mL (Use only fresh DMSO.)
• 輸送温度: ambient
• 保管温度: −20°C
• SMILES記法: [N+](=O)([O-])\C=C/c1cc2c(cc1)OCO2
• InChI: 1S/C9H7NO4/c11-10(12)4-3-7-1-2-8-9(5-7)14-6-13-8/h1-5H,6H2/b4-3-
• InChI Key: KFLWBZPSJQPRDD-ARJAWSKDSA-N

詳細

詳細

A cell-permeable nitrostyrene compound that acts as a selective inhibitor of Syk kinase activity (IC₅₀ = 2.5 µM). It inhibits Src only at much higher concentrations (IC₅₀ = 29.3 µM) and exhibits little effect against Fak and JAK2. Shown to potently inhibit platelet aggregation induced by various stimulators, including U46619, ADP, arachidonic acid, collagen, thrombin, ionophore A23187, and PDBu (IC₅₀ ranges from 2.1 to 25.9 µM).

生物化学的／生理学的作用

Cell permeable: yes

Primary Target
Syk

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 2.5 µM against Syk kinase activity

包装

Packaged under inert gas

警告

Toxicity: Irritant (B)

再構成

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

その他情報

Wang, W.Y., et al. 2006. Mol. Pharmacol.70, 1380.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• ピクトグラム: GHS07
• シグナルワード: Warning
• 危険有害性情報: H315,H319
• 注意書き: P264 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313 - P337 + P313
• 危険有害性の分類: Eye Irrit. 2 - Skin Irrit. 2
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3