614310

TLR3/dsRNA Complex Inhibitor

≥99% (HPLC), solid, TLR3/dsRNA complex inhibitor, Calbiochem^®

• 別名: TLR3/dsRNA Complex Inhibitor, ( R)-2-(3-Chloro-6-fluorobenzo[b]thiophene-2-carboxamido)-3-phenylpropanoic acid, Toll-Like Receptor 3/Double Strand RNA Complex Inhibitor, (R)-2-(3-Chloro-6-fluorobenzo[b]thiophene-2-carboxamido)-3-phenylpropanoic acid, Toll-Like Receptor 3/Double Strand RNA Complex Inhibitor
• 実験式（ヒル表記法）: C₁₈H₁₃ClFNO₃S
• 分子量: 377.82
• UNSPSCコード: 12352200
• NACRES: NA.28

特性

• product name: TLR3/dsRNA Complex Inhibitor, The TLR3/dsRNA Complex Inhibitor blocks dsRNA binding to TLR3.
• 品質水準: 100
• アッセイ: ≥99% (HPLC)
• 形状: solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; protect from light
• 色: white
• 溶解性: DMSO: 50 mg/mL
• 輸送温度: wet ice
• 保管温度: 2-8°C

詳細

詳細

A thiophenecarboxamidopropionate compound that acts as a direct, competitive and high affinity inhibitor of dsRNA binding to TLR3 (K_i = 2.96 µM; K_d = 19 nM for dsRNA binding to TLR3) and selectively antagonizes stimulated TLR3 signaling without affecting TLR1/2, TLR2/6, TLR4 and TLR7 pathways. Shown to efficiently repress TNF-α and IL-1β (IC₉₀ = 27 µM) and NO production (IC₅₀ = 3.44 µM) in Poly(I:C)-induced RAW 264.7 macrophages. Exhibits minimal cytotoxicity (IC₅₀ >>100 µM in RAW 264.7 cells) and is weakly active against a panel of 12-representative kinases and 4-cytochrome enzymes (in vitro assays).

包装

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

その他情報

Cheng, K., et al. 2011. J. Am. Chem. Soc.133, 3764.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable