8.17058

マレイン酸

EMPROVE^® ESSENTIAL, Ph. Eur., NF

• 別名: cis-ブテン二酸, トキシル酸
• 化学式: HO₂CCH=CHCO₂H
• CAS番号: 110-16-7
• 分子量: 116.07
• Beilstein: 605762
• MDL番号: MFCD00063177
• UNSPSCコード: 12352106
• EC Index Number: 203-742-5

特性

• 認証: NF; Ph. Eur.
• 品質水準: 500
• 蒸気圧: <0.1 hPa ( 20 °C)
• 製品種目: EMPROVE^® ESSENTIAL
• アッセイ: 99.0-101.0% substance (anhydrous) basis
• フォーム: solid
• 有効性: 708 mg/kg LD₅₀, oral (Rat); 1560 mg/kg LD₅₀, skin (Rabbit)
• テクニック: API processing | cocrystal formation: suitable; API processing | salt formation: suitable
• pH: 1.3 (20 °C, 100 g/L in H₂O)
• mp: 130-135 °C (lit.)
• 溶解性: 478.8 g/L
• 密度: 1.59 g/mL at 25 °C (lit.)
• 微量陽イオン: Fe: ≤5 ppm; V: ≤1 ppm; heavy metals (as Pb): ≤10 ppm
• アプリケーション: liquid formulation; pharmaceutical; semi-solid formulation; solid formulation
• 保管温度: 15-25°C
• SMILES記法: OC(=O)\C=C/C(O)=O
• InChI: 1S/C4H4O4/c5-3(6)1-2-4(7)8/h1-2H,(H,5,6)(H,7,8)/b2-1-
• InChI Key: VZCYOOQTPOCHFL-UPHRSURJSA-N

詳細

詳細

Finding the right excipient that matches your needs as well as regulatory demands can be a complicated challenge in formulation. With our application know-how and regulatory expertise, we support you in every step of development, scale-up, and production.
As part of our EMPROVE^® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC^® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

アプリケーション

Maleic acid is typically used as pH adjuster or buffer agent in pharmaceutical formulations. Maleic acid Emprove^® Essential is mainly used in highly regulated pharmaceutical applications.

法的情報

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• ピクトグラム: GHS05,GHS07
• シグナルワード: Danger
• 危険有害性情報: H302 + H312,H314,H317,H335
• 注意書き: P260 - P271 - P280 - P301 + P312 - P303 + P361 + P353 - P305 + P351 + P338
• 危険有害性の分類: Acute Tox. 4 Dermal - Acute Tox. 4 Oral - Eye Dam. 1 - Skin Corr. 1 - Skin Sens. 1 - STOT SE 3
• ターゲットの組織: Respiratory system
• 保管分類コード: 8A - Combustible corrosive hazardous materials
• WGK: WGK 1