8.52184

Fmoc-Leu-Thr(psiMe,Mepro)-OH

≥97.0% (HPLC), for peptide synthesis, Novabiochem^®

• 別名: Fmoc-Leu-Thr(psiMe,Mepro)-OH
• 実験式（ヒル表記法）: C₂₈H₃₄N₂O₆
• CAS番号: 955048-89-2
• 分子量: 494.58
• UNSPSCコード: 12352209
• NACRES: NA.22

特性

• product name: Fmoc-Leu-Thr(psiMe,Mepro)-OH, Novabiochem^®
• 品質水準: 200
• 製品種目: Novabiochem^®
• アッセイ: ≥97% (TLC); ≥97.0% (HPLC)
• 形状: powder
• 反応適合性: reaction type: Fmoc solid-phase peptide synthesis
• メーカー／製品名: Novabiochem^®
• アプリケーション: peptide synthesis
• 官能基: hydroxyl
• 保管温度: 2-8°C
• InChI: 1S/C28H34N2O6/c1-16(2)14-23(25(31)30-24(26(32)33)17(3)36-28(30,4)5)29-27(34)35-15-22-20-12-8-6-10-18(20)19-11-7-9-13-21(19)22/h6-13,16-17,22-24H,14-15H2,1-5H3,(H,29,34)(H,32,33)/t17-,23+,24+/m1/s1
• InChI Key: OTDJFZHIGWFIEW-CQLNOVPUSA-N

詳細

詳細

This pseudoproline dipeptide is undoubtedly the most effective and simplest to use tool for overcoming aggregation and enhancing peptide quality in Fmoc SPPS for peptide containing the Leu-Thr dipeptide motif. It consists of a dipeptide in which the threonine residue has been reversibly protected as a structure-breaking proline-like TFA-labile oxazolidine. The reason the pseudoproline residue is introduced as a dipeptide is because it avoids the need to acylate the hindered oxazolidine nitrogen. This has the added advantage of extending the peptide chain by two residues in one step. The threonine residue is regenerated during the normal TFA-mediated cleavage reaction.

Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Fmoc SPPS
Overcoming Aggregation in Fmoc SPPS

関連事項

Replaces: 05-20-1009

アナリシスノート

Color (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Optical rotation α 25/D (c=1 in CH₂Cl₂): -33.0 - -28.0 °
Purity (TLC(CMA2)): ≥ 97 %
Purity (TLC(157A)): ≥ 97 %
Assay (HPLC, area%): ≥ 97.0 % (a/a)
Single impurities (HPLC, area%): ≤ 2.00 % (a/a)
Acetate (IC): ≤ 0.1 %
Ethyl acetate (HS-GC): ≤ 2.0 %

To see the solvent systems used for TLC of Novabiochem^® products please click here.

法的情報

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 2
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable