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由来生物
mouse
品質水準
抗体製品の状態
purified immunoglobulin
抗体製品タイプ
primary antibodies
クローン
10H4.1, monoclonal
化学種の反応性
human, rat, mouse
テクニック
immunohistochemistry: suitable
western blot: suitable
アイソタイプ
IgMκ
NCBIアクセッション番号
UniProtアクセッション番号
輸送温度
wet ice
ターゲットの翻訳後修飾
unmodified
遺伝子情報
human ... SNAI1(6615)
詳細
SNAI1, also known as Snail homolog 1, is a transcription factor that down regulates the expression of ectodermal genes within the mesoderm and is thought to be essential for mesoderm formation in the developing embryo. SNAI1 is expressed in the kidney and in mesenchymal and epithelial cell lines. Mutations in SNAI1 have been associated with tumors.
免疫原
Epitope: N-terminus
KLH-conjugated linear peptide corresponding to the N-terminus of Human SNAIL1.
アプリケーション
Research Category
エピジェネティクス及び核内機能分子
エピジェネティクス及び核内機能分子
Research Sub Category
転写因子
転写因子
Anti-SNAI1 Antibody, clone 10H4.1 is a highly specific mouse monoclonal antibody, that targets Zinc Finger Protein & has been tested in western blotting & IHC.
Western Blotting Analysis: 0.5 µg/mL from a representative lot detected SNAIL1 in 10 µg of human and mouse kidney tissue lysate.
Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected SNAIL1 in human kidney section and human tonsil section tissues.
Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected SNAIL1 in human kidney section and human tonsil section tissues.
品質
Evaluated by Western Blotting in rat kidney tissue lysate.
Western Blotting Analysis: 0.5 µg/mL of this antibody detected SNAIL1 in 10 µg of rat kidney tissue lysate.
Western Blotting Analysis: 0.5 µg/mL of this antibody detected SNAIL1 in 10 µg of rat kidney tissue lysate.
ターゲットの説明
~29 kDa observed
物理的形状
Format: Purified
Purified mouse monoclonal IgMκ in buffer containing PBS with 0.05% sodium azide.
保管および安定性
Stable for 1 year at 2-8°C from date of receipt.
その他情報
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
免責事項
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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保管分類コード
10 - Combustible liquids
WGK
WGK 2
引火点(°F)
Not applicable
引火点(℃)
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
MABE167:
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
Li-Ting Wang et al.
EMBO reports, 21(2), e48795-e48795 (2020-01-08)
Epigenetic regulation is important for cancer progression; however, the underlying mechanisms, particularly those involving protein acetylation, remain to be fully understood. Here, we show that p300/CBP-associated factor (PCAF)-dependent acetylation of the transcription factor intestine-specific homeobox (ISX) regulates epithelial-mesenchymal transition (EMT)
Jia-Xing Sun et al.
Angiogenesis, 21(3), 635-652 (2018-04-21)
Ocular neovascularization is a comprehensive process involved in retinal vascular development and several blinding diseases such as age-related macular degeneration and retinopathy of prematurity, with vascular endothelial growth factor (VEGF) regarded as the master regulator. However, the qualified effect of
Jeong Ae Park et al.
PLoS genetics, 11(7), e1005324-e1005324 (2015-07-07)
Vascular branching morphogenesis is activated and maintained by several signaling pathways. Among them, vascular endothelial growth factor receptor 2 (VEGFR2) signaling is largely presented in arteries, and VEGFR3 signaling is in veins and capillaries. Recent reports have documented that Snail
Menggui Huang et al.
Nature cardiovascular research, 1(4), 372-388 (2022-05-17)
Myocardial infarction (MI) is a leading cause of death worldwide, largely because efficient interventions to restore cardiac function after MI are currently lacking. Here, we characterize vascular aberrancies induced by MI, and propose to target acquired endothelial cell (EC) changes
Hemin-Induced Endothelial Dysfunction and Endothelial to Mesenchymal Transition in the Pathogenesis of Pulmonary Hypertension Due to Chronic Hemolysis.
Gonzales, et al.
International Journal of Molecular Sciences, 23 (2023)
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