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Rebecca M Corrigan et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(22), 9084-9089 (2013-05-15)
Nucleotide signaling molecules are important messengers in key pathways that allow cellular responses to changing environments. Canonical secondary signaling molecules act through specific receptor proteins by direct binding to alter their activity. Cyclic diadenosine monophosphate (c-di-AMP) is an essential signaling
Paul C P Curtin et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(24), 10011-10020 (2013-06-14)
Here we applied behavioral testing, pharmacology, and in vivo electrophysiology to determine the function of the serotonin 5-HT5A receptor in goldfish startle plasticity and sensorimotor gating. In an initial series of behavioral experiments, we characterized the effects of a selective
Anusha Priya et al.
Biochimica et biophysica acta, 1833(12), 2745-2756 (2013-07-23)
N-Methyl-d-aspartate (NMDA) receptors are major glutamatergic receptors involved in most excitatory neurotransmission in the brain. The transcriptional regulation of NMDA receptors is not fully understood. Previously, we found that the GluN1 and GluN2B subunits of the NMDA receptor are regulated
Masatoshi Takagaki et al.
Experimental neurology, 252, 12-17 (2013-11-20)
Sedatives in the neurointensive care unit can strongly influence patients' risks of developing secondary brain damage. In particular, isoflurane, a volatile anesthetic, has been recently re-introduced to the neurointensive care unit, and first clinical studies suggest beneficial effects due to
Genome-wide identification and characterization of functional neuronal activity-dependent enhancers.
Athar N Malik et al.
Nature neuroscience, 17(10), 1330-1339 (2014-09-10)
Experience-dependent gene transcription is required for nervous system development and function. However, the DNA regulatory elements that control this program of gene expression are not well defined. Here we characterize the enhancers that function across the genome to mediate activity-dependent
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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