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Merck

PHR1319

Supelco

トリクロロエチレン

Pharmaceutical Secondary Standard; Certified Reference Material

別名:

TCE, トリクロロエテン

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About This Item

化学式:
ClCH=CCl2
CAS番号:
分子量:
131.39
Beilstein:
1736782
MDL番号:
UNSPSCコード:
41116107
PubChem Substance ID:

グレード

certified reference material
pharmaceutical secondary standard

品質水準

認証

traceable to USP 1601827

蒸気密度

4.5 (vs air)

蒸気圧

61 mmHg ( 20 °C)

CofA

current certificate can be downloaded

自己発火温度

770 °F

テクニック

HPLC: suitable
gas chromatography (GC): suitable

屈折率

n20/D 1.476 (lit.)

bp

86.7 °C (lit.)

mp

−84.8 °C (lit.)

密度

1.463 g/mL at 25 °C (lit.)

アプリケーション

pharmaceutical (small molecule)

フォーマット

single component solution

保管温度

2-30°C

SMILES記法

Cl\C=C(\Cl)Cl

InChI

1S/C2HCl3/c3-1-2(4)5/h1H

InChI Key

XSTXAVWGXDQKEL-UHFFFAOYSA-N

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詳細

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Residual Solvent - Trichloroethylene belongs to the group of class 2 residual solvents. The use of class 2 solvents should be limited in drug substances, excipients, dietary ingredients, and official products because of the inherent toxicities of these residual solvents. Trichloroethylene is a volatile and chlorinated organic compound, which finds applications as a solvent and greasing agent.

アプリケーション

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

その他情報

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

脚注

To see an example of a Certificate of Analysis for this material enter LRAA0678 in the slot below. This is an example certificate only and may not be the lot that you receive.

ピクトグラム

Health hazard

シグナルワード

Danger

危険有害性情報

危険有害性の分類

Carc. 1B

保管分類コード

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

引火点(°F)

188.6 °F - closed cup

引火点(℃)

87 °C - closed cup


適用法令

試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。

PRTR

特定第一種指定化学物質

消防法

第4類:引火性液体
第三石油類
危険等級III
非水溶性液体

労働安全衛生法名称等を表示すべき危険物及び有害物

名称等を表示すべき危険物及び有害物

労働安全衛生法名称等を通知すべき危険物及び有害物

名称等を通知すべき危険物及び有害物

Jan Code

PHR1319-3X1.2ML:
PHR1319-1.2ML-PW:


試験成績書(COA)

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Slide 1 of 1

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Michihiro Kamijima et al.
International archives of occupational and environmental health, 80(5), 357-370 (2006-11-16)
Workers exposed to trichloroethylene (TCE) rarely show severe generalized skin disorders and accompanying hepatitis which resemble drug hypersensitivities. The disorders are completely different from solvent-induced irritating contact dermatitis, and their serious consequences have become one of the critical occupational health
Glinda S Cooper et al.
Environmental health perspectives, 117(5), 696-702 (2009-05-30)
Our objective was to examine experimental and epidemiologic studies pertaining to immune-related, and specifically autoimmune-related, effects of trichloroethylene (TCE). We performed a literature search of PubMed and reviewed bibliographies in identified articles. We then systematically reviewed immune-related data, focusing on
David J Jollow et al.
Critical reviews in toxicology, 39(9), 782-797 (2009-10-27)
Trichloroethylene (TCE) is a widespread environmental contaminant that is carcinogenic when given in high, chronic doses to certain strains of mice and rats. The capacity of TCE to cause cancer in humans is less clear. The current maximum contaminant level
Dominik D Alexander et al.
International archives of occupational and environmental health, 81(2), 127-143 (2007-05-12)
Findings from epidemiologic studies of trichloroethylene (TCE) exposure and liver cancer have been inconsistent. To quantitatively evaluate this association and to examine sources of heterogeneity, we conducted a meta-analysis of occupational studies of TCE exposure and liver/biliary tract cancer. We
Cheryl Siegel Scott et al.
Environmental health perspectives, 114(9), 1471-1478 (2006-09-13)
A large body of epidemiologic evidence exists for exploring causal associations between cancer and trichloroethylene (TCE) exposure. The U.S. Environmental Protection Agency 2001 draft TCE health risk assessment concluded that epidemiologic studies, on the whole, support associations between TCE exposure

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