PHR1797

イミプラミン 塩酸塩

Pharmaceutical Secondary Standard; Certified Reference Material

• 別名: 10,11-ジヒドロ-N,N-ジメチル-5H-ジベンゾ[b,f]アゼピン-5-プロパンアミン 塩酸塩, 5-[3-(ジメチルアミノ)プロピル]-10,11-ジヒドロ-5H-ジベンゾ[b,f]アゼピン 塩酸塩
• 実験式（ヒル表記法）: C₁₉H₂₄N₂ · HCl
• CAS番号: 113-52-0
• 分子量: 316.87
• EC Number: 204-030-7
• MDL番号: MFCD00012669
• UNSPSCコード: 41116107
• PubChem Substance ID: 329823621
• NACRES: NA.24

特性

• グレード: certified reference material; pharmaceutical secondary standard
• 品質水準: 300
• 認証: traceable to BP 932; traceable to Ph. Eur. I0100000; traceable to USP 1338007
• APIファミリー: imipramine
• CofA: current certificate can be downloaded
• 包装: pkg of 1 g
• テクニック: HPLC: suitable; gas chromatography (GC): suitable
• アプリケーション: pharmaceutical (small molecule)
• フォーマット: neat
• 保管温度: 2-30°C
• SMILES記法: Cl[H].CN(C)CCCN1c2ccccc2CCc3ccccc13
• InChI: 1S/C19H24N2.ClH/c1-20(2)14-7-15-21-18-10-5-3-8-16(18)12-13-17-9-4-6-11-19(17)21;/h3-6,8-11H,7,12-15H2,1-2H3;1H
• InChI Key: XZZXIYZZBJDEEP-UHFFFAOYSA-N
• 遺伝子情報: human ... SLC6A2(6530) , SLC6A4(6532)

詳細

詳細

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Imipramine Hydrochloride is typically utilized for the treatment of depressive disorders due to its efficiency in uplifting the patients′ mood by interfering in the reuptake of norepinephrine or serotonin.

アプリケーション

Imipramine Hydrochloride may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by chromatography and spectrophotometry techniques.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

生物化学的／生理学的作用

三環系抗うつ剤です。セロトニン輸送体、ノルエピネフリン輸送体を阻害します (各K_i値は7.7 nM、67 nM)。ド-パミン輸送体にはほとんど影響しません (K_i=25 μM)。

三環系抗うつ剤です。セロトニン輸送体およびノルエピネフリン輸送体を阻害します。ド-パミン輸送体にはほとんど影響しません。

アナリシスノート

このような2次標準は、入手可能な場合にはUSP、EP、BPの1次標準にマルチトレーサビリティを提供します。

その他情報

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

脚注

To see an example of a Certificate of Analysis for this material enter LRAA8623 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

安全性情報

• ピクトグラム: GHS06
• シグナルワード: Danger
• 危険有害性情報: H300
• 注意書き: P264 - P270 - P301 + P310 - P405 - P501
• 危険有害性の分類: Acute Tox. 2 Oral
• 保管分類コード: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable