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生物化学的／生理学的作用
ステロール、ドリコール、ヘム、およびユビキノンの生合成に重要な役割を果たすメバロン酸経路の代謝産物。対象は腫瘍学、自己免疫疾患、アテローム性動脈硬化症、アルツハイマー病の疾病分野、およびメバロン酸キナーゼの遺伝性欠損症の研究。
包装
底の開いたガラス瓶内容物は内部に挿入され接着された円錐部に入っています。
保管分類コード
11 - Combustible Solids
WGK
WGK 3
引火点(°F)
Not applicable
引火点(℃)
Not applicable
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Adelene Ai-Lian Song et al.
PloS one, 7(12), e52444-e52444 (2013-01-10)
Isoprenoids are a large and diverse group of metabolites with interesting properties such as flavour, fragrance and therapeutic properties. They are produced via two pathways, the mevalonate pathway or the 2-C-methyl-D-erythritol-4-phosphate (MEP) pathway. While plants are the richest source of
Ai Hosaka et al.
Neurochemical research, 38(3), 589-600 (2012-12-28)
Statins, 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors, have been reported to attenuate amyloid-β peptide (Aβ) production in various cellular models. However, the mechanisms by which statins affect neuronal Aβ production have not yet been clarified. Here, we investigated this issue in
Martin Thurnher et al.
Biochimica et biophysica acta, 1831(6), 1009-1015 (2013-03-26)
The mevalonate pathway is a highly conserved metabolic cascade and provides isoprenoid building blocks for the biosynthesis of vital cellular products such as cholesterol or prenyl pyrophosphates that serve as substrates for the posttranslational prenylation of numerous proteins. The pathway
Jianxin Shi et al.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 34(1), 429-435 (2012-11-28)
Esophageal squamous cell carcinoma (ESCC) is one of the most common lethal tumors in the world. Thus, it is very urgent to develop new therapeutic targets against this disease. The mevalonate (MVA) pathway, paced by its rate-limiting enzyme, hydroxymethylglutaryl coenzyme
Jordi Pérez-Gil et al.
The Biochemical journal, 452(1), 19-25 (2013-04-26)
Isoprenoids are a large family of compounds synthesized by all free-living organisms. In most bacteria, the common precursors of all isoprenoids are produced by the MEP (methylerythritol 4-phosphate) pathway. The MEP pathway is absent from archaea, fungi and animals (including
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