おすすめの製品
品質水準
アッセイ
>98% (HPLC)
フォーム
solid
色
white
mp
132.5-137.4 °C (lit.)
溶解性
DMSO: soluble 22 mg/mL
SMILES記法
OC(=O)Cc1ccc(CCNS(=O)(=O)c2ccc(Cl)cc2)cc1
InChI
1S/C16H16ClNO4S/c17-14-5-7-15(8-6-14)23(21,22)18-10-9-12-1-3-13(4-2-12)11-16(19)20/h1-8,18H,9-11H2,(H,19,20)
InChI Key
IULOBWFWYDMECP-UHFFFAOYSA-N
遺伝子情報
human ... TBXA2R(6915)
詳細
Exerts protective effects on brain infarction, heart cell injury due to hypoxia and hypoglycemia and lowers serum CPK activity.
生物化学的／生理学的作用
Selective thromboxane A2 receptor antagonist
特徴および利点
This compound is featured on the Prostanoid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
シグナルワード
Warning
危険有害性情報
危険有害性の分類
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
ターゲットの組織
Respiratory system
保管分類コード
11 - Combustible Solids
WGK
WGK 3
引火点(°F)
Not applicable
引火点(℃)
Not applicable
個人用保護具 (PPE)
dust mask type N95 (US), Eyeshields, Gloves
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
D7441-VAR:
D7441-5MG:
D7441-BULK:
D7441-25MG:
最新バージョンのいずれかを選択してください：
U Grandel et al.
Circulation, 102(22), 2758-2764 (2000-11-30)
Although endotoxin (lipopolysaccharides, LPS) is recognized as a mediator of septic cardiodepression, its cardiac effects are still not fully elucidated. Perfusion of isolated rat hearts with LPS for 180 minutes resulted in a decline of left ventricular contractility after 90
Anna K Leal et al.
American journal of physiology. Heart and circulatory physiology, 301(5), H2140-H2146 (2011-08-23)
Cyclooxygenase metabolites stimulate or sensitize group III and IV muscle afferents, which comprise the sensory arm of the exercise pressor reflex. The thromboxane (TP) receptor binds several of these metabolites, whose concentrations in the muscle interstitium are increased by exercise
Growth inhibitory effects of thromboxane antagonists on breast cancer cell lines: a preliminary study.
K Marshall et al.
Advances in experimental medicine and biology, 400A, 455-460 (1997-01-01)
T Tanaka et al.
European journal of pharmacology, 357(1), 53-60 (1998-10-27)
We investigated the pharmacological characteristics of Z-335 ((+/-)-sodium[2-[4-(chlorophenylsulfonylaminomethyl)indan-5-yl]ace tate monohydrate), a new indan derivative. Z-335 inhibited the specific binding of [3H]SQ-29548 to human platelets and guinea pig platelet membranes. The IC50 values of Z-335 for human platelets and guinea pig
M Rathaus et al.
Clinical science (London, England : 1979), 88(6), 623-627 (1995-06-01)
1. In previous works we have described the development of hypertension and aggravation of proteinuria in rats who became pregnant after the administration of Adriamycin. This was associated with an increase in the glomerular thromboxane B2-prostaglandin E2 ratio. 2. To
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