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品質水準
アッセイ
≥98% (HPLC)
フォーム
powder
色
white
溶解性
DMSO: 10 mg/mL, clear
H2O: insoluble
保管温度
2-8°C
SMILES記法
COc1ccc(CCNC[C@H](O)c2ccc(O)cc2)cc1OC
InChI
1S/C18H23NO4/c1-22-17-8-3-13(11-18(17)23-2)9-10-19-12-16(21)14-4-6-15(20)7-5-14/h3-8,11,16,19-21H,9-10,12H2,1-2H3/t16-/m0/s1
InChI Key
VHSBBVZJABQOSG-INIZCTEOSA-N
遺伝子情報
human ... ADRB1(153)
アプリケーション
R(-)-Denopamine has been used as an β-adrenergic agonist to study its effects on contractility in isolated lymphatic vessels (LVs).
生物化学的／生理学的作用
β1-adrenoceptor agonist.
Denopamine is a cardiotonic drug.
特徴および利点
This compound is featured on the β-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
注意
光に不安定です。
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
D7815-5MG:
D7815-BULK:
D7815-IP:
D7815-VAR:
D7815-25MG:
T Bando et al.
Oncology reports, 7(1), 49-52 (1999-12-22)
Cisplatin is a key drug in chemotherapy for lung cancer. It has been reported that intracellular accumulation of cisplatin is an important step as a determinant for resistance to cisplatin, which may be modulated by Na+, K+-ATPase activity. And it
Hidefumi Kaji et al.
Drug metabolism and disposition: the biological fate of chemicals, 33(3), 403-412 (2004-12-21)
Denopamine is one of the oral beta(1)-adrenoceptor-selective partial agonists. Denopamine glucuronide is the most abundant metabolite in human, rat, and dog urine when administered orally. Species differences in denopamine glucuronidation were investigated with liver microsomes obtained from humans and experimental
A Distinct Role of the Autonomic Nervous System in Modulating the Function of Lymphatic Vessels under Physiological and Tumor-Draining Conditions
Bachmann SB, et al.
Testing, 27(11), 3305-3314 (2019)
S Chiba et al.
Journal of autonomic pharmacology, 21(1), 7-13 (2001-06-26)
1. Using the cannula inserting method, vasodilator responses to beta-adrenoceptor agonists (isoprenaline, denopamine and procaterol) were investigated in isolated and perfused rat common carotid arteries. 2. Each beta-adrenoceptor agonist induced a vasodilation in preparations preconstricted by phenylephrine in a dose-related
N Ohashi et al.
Journal of pharmaceutical and biomedical analysis, 18(3), 325-334 (1999-03-30)
The usefulness of the hydrogen-deuterium (H-D) exchange method in the study of drug metabolism was investigated. Metabolite samples of denopamine and promethazine prepared in vitro were introduced to a triple stage quadrupole tandem mass spectrometer via a high performance liquid
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