F3393

抗線維芽細胞増殖因子-塩基性 (1-24) ウサギ宿主抗体

fractionated antiserum, lyophilized powder

• 別名: 抗FGF2抗体, 抗bFGF抗体
• MDL番号: MFCD01322020
• UNSPSCコード: 12352203
• NACRES: NA.41
• 結合体: unconjugated
• application: ELISA (i); IHC (p); WB
• クローン: polyclonal
• 化学種の反応性: human, bovine, rat
• citations: 14
• テクニック: immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable; indirect ELISA: suitable; western blot: 1:1,000

特性

• 由来生物: rabbit
• 品質水準: 200
• 結合体: unconjugated
• 抗体製品の状態: fractionated antiserum
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• フォーム: lyophilized powder
• 化学種の反応性: human, bovine, rat
• テクニック: immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable; indirect ELISA: suitable; western blot: 1:1,000
• 不純物: endotoxin, tested
• UniProtアクセッション番号: P09038
• アプリケーション: research pathology
• 保管温度: 2-8°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: bovine ... FGF2(281161) ; human ... FGF2(2247) ; rat ... Fgf2(54250)

詳細

詳細

Fibroblast growth factor-basic (FGFb), also known as NUDT6 (nudix (nucleoside diphosphate linked moiety X)-type motif 6) is encoded by the gene mapped to human chromosome 4q28.1. The FGFb gene spanning 34271 bp on genomic DNA contains 16 exons and six introns. FGFb RNA transcripts are expressed in various human tissues including liver, thymus, spleen, peripheral blood leukocytes, heart skeletal muscle, testis, colon and kidney.

免疫原

ウシFGF2 (1-24) に相当する合成ペプチド。

アプリケーション

Anti-Fibroblast Growth Factor-Basic (1-24) antibody produced in rabbit has been used in:

• immunohistochemistry
• immunostaining
• immunoblotting

生物化学的／生理学的作用

Fibroblast Growth Factor Basic (also known as bFGF) is a pleotropic cytokine that that is a potent mitogenic factor. On binding to its cognate receptor tyrosine kinase, FGFR, bFGF is capable of activation of pathways such as MAPK and PI3K and produce cellular effects in varied cell types. Fibroblast Growth Factor-basic is reported to induce proliferation of fibroblasts, differentiation, wound healing and regeneration, limb formation, tissue remodeling and angiogenesis.

物理的形状

凍結乾燥品 (PBS溶液, 0.2μmフィルタ-濾過)

アナリシスノート

Bioactivity: Anti-Fibroblast Growth Factor-Basic (1-24) caused a dose-dependent decrease in the mitogenic activity of FGF-Basic such that a final dilution of 1:50 neutralized the bioactivity of 1 unit of FGF Basic.

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): Eyeshields, Gloves, type N95 (US)