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由来生物
human
品質水準
リコンビナント
expressed in E. coli
アッセイ
>95% (SDS-PAGE and HPLC)
フォーム
lyophilized powder
有効性
≤0.5 ng/mL
分子量
predicted mol wt 21.2 kDa
包装
pkg of 25 μg
保管条件
avoid repeated freeze/thaw cycles
不純物
endotoxin, tested
UniProtアクセッション番号
保管温度
−20°C
遺伝子情報
human ... FGF18(8817)
詳細
FGF18 (fibroblast growth factor 18) is a member of the FGF family, and is a part of the FGF8 subfamily, which also includes FGF8 and FGF17. It is a paracrine-acting protein, and does not undergo alternative splicing. It is produced as a precursor of 207 amino acids, from which the signal peptide of 27 hydrophobic amino acids is cleaved of. This gene is localized to human chromosome 5q35.1, which produces a protein of 21.2kDa.
生物化学的／生理学的作用
FGF-18はヘパリン結合性の増殖因子であり、FGFレセプタ-を発現する細胞の増殖や活性化を刺激します。
FGF18 (fibroblast growth factor 18) functions in both developing and adult organisms, and plays a predominant role in skeletal development. It is a putative early marker for prostate and ovarian cancer, and has potential as a target in the same. It mediates gene profiling, and has anticatabolic effects mediated through Timp1 (tissue inhibitor of metalloproteinases). Thus, it has confers protection on adult articular cartilage. In mice embryos, inactivation of this gene results in death due to aberrations in alveologenesis and skeleton development.
物理的形状
凍結乾燥品(0.2 μmフィルターで濾過滅菌済み、10 mM Tris溶液、pH 8.0、20 mM NaCl)。
アナリシスノート
生物活性は、FGFレセプタ-を発現するBaF3細胞のチミジン取り込みに対する用量依存的な刺激作用により測定しています。
シグナルワード
Warning
危険有害性情報
危険有害性の分類
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
ターゲットの組織
Respiratory system
保管分類コード
11 - Combustible Solids
WGK
WGK 2
引火点(°F)
Not applicable
引火点(℃)
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
F7301-BULK:
F7301-25UG-PW:
F7301-VAR:
F7301-25UG:
最新バージョンのいずれかを選択してください：
The crystal structure of fibroblast growth factor 18 (FGF18).
Alan Brown et al.
Protein & cell, 5(5), 343-347 (2014-03-29)
Wei Wei et al.
The Journal of clinical investigation, 123(10), 4435-4448 (2013-09-11)
High-throughput genomic technologies have identified biomarkers and potential therapeutic targets for ovarian cancer. Comprehensive functional validation studies of the biological and clinical implications of these biomarkers are needed to advance them toward clinical use. Amplification of chromosomal region 5q31-5q35.3 has
Yoshifumi Mori et al.
The Journal of biological chemistry, 289(14), 10192-10200 (2014-03-01)
To identify genes that maintain the homeostasis of adult articular cartilage and regenerate its lesions, we initially compared four types of chondrocytes: articular (AA) versus growth plate (AG) cartilage chondrocytes in adult rats, and superficial layer (IS) versus deep layer
Shuk Yee Ngan et al.
Current protocols, 2(1), e341-e341 (2022-01-14)
Human embryonic stem cells (ES) and induced pluripotent stem cells (iPSC) are powerful tools that have the potential to generate in vitro human lung epithelial cells. However, challenges in efficiency and reproducibility remain in utilizing the cells for therapy discovery
Amy P Wong et al.
Nature protocols, 10(3), 363-381 (2015-02-06)
Airway epithelial cells are of great interest for research on lung development, regeneration and disease modeling. This protocol describes how to generate cystic fibrosis (CF) transmembrane conductance regulator protein (CFTR)-expressing airway epithelial cells from human pluripotent stem cells (PSCs). The
資料
Fibroblast growth factors in cell culture and various growth factors for your research
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