F9679

抗脂肪酸シンターゼ (C-末端) ウサギ宿主抗体

1 mg/mL, affinity isolated antibody, buffered aqueous solution

• 別名: 抗FASN抗体, 抗FAS抗体
• MDL番号: MFCD00283209
• UNSPSCコード: 12352203
• NACRES: NA.41
• 結合体: unconjugated
• application: WB
• クローン: polyclonal
• 化学種の反応性: mouse, rat, human
• citations: 9
• テクニック: western blot: 0.5-1 μg/mL using lysates of Rat1 cells; western blot: 1-2 μg/mL using lysates of human HEK 293-T cells

特性

• 由来生物: rabbit
• 品質水準: 200
• 結合体: unconjugated
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• フォーム: buffered aqueous solution
• 分子量: antigen 270 kDa
• 化学種の反応性: mouse, rat, human
• 濃度: 1 mg/mL
• テクニック: western blot: 0.5-1 μg/mL using lysates of Rat1 cells; western blot: 1-2 μg/mL using lysates of human HEK 293-T cells
• UniProtアクセッション番号: P49327
• 輸送温度: dry ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... FASN(2194) ; mouse ... Fasn(14104) ; rat ... Fasn(50671)

詳細

詳細

Fatty acid synthase (FAS, FASN) is a multifunctional protein, mainly involved in catalyzing the synthesis of palmitate from acetyl-CoA and malonyl CoA, in the presence of NADPH. In mammals, it is composed of two identical multifunctional polypeptides, in which three catalytic domains in the N-terminal section (β-ketoacyl synthase, malonyl/acetyl tansferase, and dehydrase) are separated by a core region of about 600 residues from four C-terminal domains (enoyl reductase, β-ketoacyl reductase, acyl carrier protein, and thioesterase).

免疫原

ヒト脂肪酸シンタ-ゼのアミノ酸2497-2511に相当する合成ペプチド(N末端リジン付加)のKLH結合体。相当する配列はヒト、ラット、マウスで保存されています。

アプリケーション

Anti-Fatty Acid Synthase (C-Terminal) antibody is suitable for western blot analysis at a concentration of 0.5-1μg/mL using lysates of Rat1 cells and 1-2μg/mL using lysates of human HEK 293-T cells.

生物化学的／生理学的作用

FAS plays an essential role during embryogenesis and energy homeostasis in adult animals. It also acts as the carbon source for fatty acid synthesis. It has been shown to be overexpressed in various types of human cancer, including prostate, breast, ovary and others.

物理的形状

0.01M PBS溶液 (pH 7.4, 15mMアジ化ナトリウム含有)。

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)