G4416

抗GABA_A 受容体 (α1 サブユニット) ウサギ宿主抗体

affinity isolated antibody

• MDL番号: MFCD01092338
• UNSPSCコード: 12352203
• NACRES: NA.41
• 結合体: unconjugated
• application: IHC; WB
• クローン: polyclonal
• 化学種の反応性: mouse, rat, human (predicted), bovine (predicted), chicken (predicted)
• citations: 12
• テクニック: immunohistochemistry: suitable using rat brain sections; western blot: 1:400-1:1,000 using rat brain membranes

特性

• 由来生物: rabbit
• 品質水準: 100
• 結合体: unconjugated
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• フォーム: lyophilized powder
• 分子量: antigen ~50 kDa
• 化学種の反応性: mouse, rat, human (predicted), bovine (predicted), chicken (predicted)
• テクニック: immunohistochemistry: suitable using rat brain sections; western blot: 1:400-1:1,000 using rat brain membranes
• UniProtアクセッション番号: P14867
• 保管温度: −20°C
• 遺伝子情報: human ... GABRA1(2554) ; mouse ... Gabra1(14394) ; rat ... Gabra1(29705)

詳細

詳細

GABAA and GABAB receptors differ with regard to their ionic characteristics and pharmacological properties. The GABAA receptor is an ionotropic receptor that forms the GABA gated chloride channel and consists of several heterogeneous subunits with membrane recognition sites for benzodiazapenes.

免疫原

ラットGABA(A)レセプタ-α1サブユニットのアミノ酸28-43に相当するペプチド。

アプリケーション

Anti-GABAA Receptor (α1 subunit) antibody produced in rabbit is suitable for detection of GABA-A α1 subunit by immunohistochemistry using rat brain sections and by immunoblotting at a working dilution of 1:400-1:1000 using rat brain membranes.

生物化学的／生理学的作用

The inhibitory neurotransmitter GABA signals through two distinct types of pre- and postsynaptic receptors, GABAA and GABAB. Both GABA receptors can regulate depression of synaptic transmission and be involved in the inhibition controlling neuronal excitability. α1 is a subtype of GABAA receptor expressed selectively by serotonergic and GABAergic neurons. Serotonergic neurons express strong α3 immunoreactivity but, do not show any α1 immunoreactivity. On the contrary, GABAergic neurons express both α1 and α3 subunits.

物理的形状

凍結乾燥品 (PBS, pH 7.4, 1%BSA, 0.05%アジ化ナトリウム含有)。

調製ノート

0.05 mLのバイアルは、50 μLの脱イオン水で復元してください。0.2 mLのバイアルは、0.2 mLの脱イオン水で復元してください。復元後の抗体濃度は約0.8 mg/mLです。

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 2
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable