H1917

Histone H1 human

• 別名: Histone, Human
• CAS番号: 1523001-32-2
• UNSPSCコード: 12352202
• NACRES: NA.25

特性

• 由来生物: human
• 品質水準: 200
• リコンビナント: expressed in E. coli
• 形状: liquid
• 濃度: 1 mg/mL
• UniProtアクセッション番号: P07305
• 輸送温度: wet ice
• 保管温度: −20°C
• 遺伝子情報: human ... H1.0(3005)

詳細

詳細

Histone H1 is part of high-order chromatin structure and is a linker protein associated with nucleosome core particle. Histone H1 is mapped to human chromosome 6. Histone H1 exists in different isoforms. Histone H1 comprises of N-terminal hydrophobic rich region, central globular domain and a C-terminal with intrinsically disordered regions.

生物化学的／生理学的作用

The C-terminal regions of histone H1 is essential for binding to chromatin. The placement of H1 is necessary for nucleosome positioning. Histone H1 maintains chromosome architecture and stabilises compaction of nucleosomes during interphase. H1-null mutants display increased rate of chromatin aberration and growth defects. Histone H1 modulates embryogenesis and DNA repair. The H1 histone undergoes posttranslational modification including phosphorylation, methylation and acetylation, each of which carry out different physiological functions. Histone H1 and its variants contribute to the pathogenesis in cancer, Alzheimer′s disease, male infertility and immunity related disorders.

物理的形状

Supplied as 1 mg/mL in 20 mM NaPO₄, pH 7.0, 0.3 M NaCl, 1 mM EDTA, and 1 mM DTT.

安全性情報

• ピクトグラム: GHS07
• シグナルワード: Warning
• 危険有害性情報: H319
• 注意書き: P264 - P280 - P305 + P351 + P338 - P337 + P313
• 危険有害性の分類: Eye Irrit. 2
• 保管分類コード: 12 - Non Combustible Liquids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable