HPA026853

Anti-SMARCC1 antibody produced in rabbit

Prestige Antibodies^® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

• 別名: Anti-BAF155, Anti-CRACC1, Anti-Rsc8, Anti-SRG3, Anti-SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1
• MDL番号: MFCD09265420
• UNSPSCコード: 12352203
• Human Protein Atlas Number: HPA026853
• NACRES: NA.41

特性

• 由来生物: rabbit
• 品質水準: 100
• 結合体: unconjugated
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• 製品種目: Prestige Antibodies^® Powered by Atlas Antibodies
• 形状: buffered aqueous glycerol solution
• 化学種の反応性: human
• 強化検証: orthogonal RNAseq; Learn more about Antibody Enhanced Validation
• テクニック: immunoblotting: 0.04-0.4 μg/mL; immunofluorescence: 0.25-2 μg/mL; immunohistochemistry: 1:50-1:200
• 免疫原配列: AHVKKVQEAARASGKVDPTYGLESSCIAGTGPDEPEKLEGAEEEKMEADPDGQQPEKAENKVENETDEGDKAQDGENEKNSEKEQDSEVSEDTKSEEKETEENKELTDTCKERESDTGKKKVEHEISEGNVATAAAAALASAATKAKHL
• UniProtアクセッション番号: Q92922
• 輸送温度: wet ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... SMARCC1(6599)

詳細

詳細

SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1 (SMARCC1), also referred to as BRG1-associated factor 155 (BAF155), is encoded by the gene mapped to human chromosome 3p21.31. The encoded protein is expressed ubiquitously and characterized with the leucine zipper or proline/glutamine rich domain at C- terminal.

免疫原

SMARCC1(SWI/SNF関連, マトリクス結合, アクチン依存性クロマチン調節因子サブファミリーcメンバー1)のPrEST(protein epitope signature tag)抗原リコンビナントタンパク質。

アプリケーション

Prestige抗体^®は、Human Proteome Resource(HPR)プロジェクト (www.proteinatlas.org)によって開発・実証されたAtlas抗体です。抗体はすべて、数百の正常組織・疾病組織に対する免疫組織染色試験を行っています。これらの染色画像はHuman Protein Atlas(HPA)サイトで[Image Gallery]リンクをクリックするとご覧いただけます。さらに、ほとんどのPrestige抗体はプロテインアレイおよびウェスタンブロッティングの試験を行っています。試験の プロトコール およびPrestige抗体、HPAに関する情報は sigma.com/prestigeをご覧ください。

生物化学的／生理学的作用

SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1 (SMARCC1) protein/ BRG1-associated factor 155 (BAF155) is the one of the vital components of intra-nuclear SWI/SNF complex, which promotes the transactivation of the androgen receptor. The encoded protein is overexpressed in case of prostate cancer (PC), thus it can be used as a potential marker for PC progression. SMARCC1 is associated with tumor dedifferentiation, progression, metastasis and it functions as a human tumor suppressor gene. SRG3 mouse homologue of SMARCC1 is required for early embryogenesis, T-cell differentiation and brain development. It also plays an essential role in targeted chromatin remodeling and transcriptional activation by erythroid Kruppel-Like factor (EKLF) in vitro.

特徴および利点

Prestige Antibodies^® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies^® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:

• IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
• Protein array of 364 human recombinant protein fragments.

関連事項

Corresponding Antigen APREST70986

物理的形状

PBS溶液(pH 7.2, 40%グリセロールおよび0.02%アジ化ナトリウム含有)。

法的情報

Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable