I0523

IL-2 mouse

≥97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

• 別名: mIL-2, IL-2, T細胞増殖因子
• MDL番号: MFCD00164816
• UNSPSCコード: 12352202
• NACRES: NA.77

特性

• 製品名: インターロイキン-2 マウス由来, IL-2, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture
• 由来生物: mouse
• 品質水準: 200
• リコンビナント: expressed in E. coli
• アッセイ: ≥97% (SDS-PAGE)
• フォーム: lyophilized powder
• 有効性: ≤0.2 ng/mL ED₅₀
• 品質: endotoxin tested
• 分子量: 17.2 kDa
• 包装: pkg of 5X20 μg; pkg of 20 μg
• テクニック: cell culture | mammalian: suitable
• 不純物: ≤1.000 EU/μg
• 色: white
• UniProtアクセッション番号: P04351
• 保管温度: −20°C
• 遺伝子情報: mouse ... Il2(16183)

詳細

詳細

IL-2 (interleukin-2) codes for a pro-inflammatory cytokine. IL-2 is mostly expressed in T helper cells.

アプリケーション

Interleukin-2 from mouse has been used to induce sepsis in rat model. It has also been used in dendritic epidermal T cell culture.

生物化学的／生理学的作用

Interleukin-2 (IL-2) is an immunomodulatory factor produced by certain subsets of T lymphocytes. This lymphokine promotes long-term growth of activated T cells and related cell types. IL-2 plays a role in the activation and proliferation of natural killer cells, induces γ-interferon and B cell growth factor secretion, and modulates the expression of the IL-2 receptor. IL-2 expression is known to reduce with age and results in influenza infection, neoplasms and lethal autoimmunity. IL-2 participates in T cell proliferation and differentiation and controls the homeostasis of T cell. As a part of immune response, IL-2 stimulates the action of T helper cell 1 and 2 along with endothelial white blood cells of skeletal muscles. IL-2 regulation is controlled by c-rel protein. IL-2 is a neurotrophic molecule and has special functions in cortical, hippocampal, septal, cerebellar and retinal neurons.

物理的形状

Lyophilized from a 0.2 μm filtered solution in 10 mM sodium citrate, pH 4.0.

アナリシスノート

活性は、マウスCTLL-2細胞の用量依存的な刺激作用により決定しています。ED₅₀:≦0.2 ng/mL(比活性5×10⁶ units/mg相当)。

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): Eyeshields, Gloves, type N95 (US)