I3392

Anti-Interleukin-1α antibody produced in goat

IgG fraction of antiserum, lyophilized powder

• 別名: Anti-IL-1α
• MDL番号: MFCD00165461
• UNSPSCコード: 51111800
• NACRES: NA.41
• 結合体: unconjugated
• application: ELISA (i); Neutral; WB
• クローン: polyclonal
• 化学種の反応性: mouse
• citations: 6
• テクニック: indirect ELISA: suitable; neutralization: suitable; western blot: suitable

特性

• 由来生物: goat
• 品質水準: 100
• 結合体: unconjugated
• 抗体製品の状態: IgG fraction of antiserum
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• フォーム: lyophilized powder
• 化学種の反応性: mouse
• テクニック: indirect ELISA: suitable; neutralization: suitable; western blot: suitable
• UniProtアクセッション番号: P01582
• 保管温度: −20°C
• 遺伝子情報: mouse ... Il1a(16175)

詳細

詳細

Interleukins are proinflammatory cytokines produced on cell injury or trauma. There are two closely related types of interleukins produced by the cell, IL-1α and IL-1β that are produced by the activation of NF-κ B transcription factor in response to bacterial infection or LPS. Both IL-1α and IL-1β exert their cellular effects by signalling through IL-1 receptor type 1. A variety of cells such as macrophages, epithelial cells, fibroblasts, keratinocytes, monocytes and dendritic cells secrete IL-1α. Both IL-1α and IL-1β are important in acquired immunity, inflammation, response to infection and production of matrix metalloproteinases (MMPs). The effects of IL-1α are mediated by activation of NF-κB, JNK and MAPK pathways that activated the genes in response to infection and inflammation. Overproduction of IL-1α has been implicated in inflammatory disorders like rheumatoid arthritis and periodontitis
Anti-interleukin-1α specifically reacts with mouse IL-1α. It does not react with human IL-1α and IL-1β or mouse IL-1β.

特異性

The antibody will neutralize the biological activity of recombinant mouse IL-1α, but not recombinant human IL-1α, IL-1β or recombinant mouse IL-1β.

免疫原

recombinant mouse IL-1α.

アプリケーション

Anti-interleukin 1α antibody is suitable for neutralization reactions and the recommended ND50 is 0.04-0.2 μg/ml. The antibody may be used for immunoblotting at a working concentration of 1-2 μg/ml. It is also suitable for indirect ELISA applications.

物理的形状

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline pH 7.4, with 5% trehalose.

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): Eyeshields, Gloves, type N95 (US)