I3767

抗インターロイキン-1β抗体 ヤギ宿主抗体

IgG fraction of antiserum

• 別名: 抗IL-1β抗体
• MDL番号: MFCD00240949
• UNSPSCコード: 12352203
• NACRES: NA.41
• 結合体: unconjugated
• application: Neutral; WB
• クローン: polyclonal
• 化学種の反応性: mouse
• citations: 17
• テクニック: neutralization: suitable; western blot: suitable

特性

• 由来生物: goat
• 品質水準: 200
• 結合体: unconjugated
• 抗体製品の状態: IgG fraction of antiserum
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• 化学種の反応性: mouse
• テクニック: neutralization: suitable; western blot: suitable
• UniProtアクセッション番号: P10749
• 保管温度: −20°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: mouse ... Il1b(16176)

詳細

詳細

Interleukins are proinflammatory cytokines produced on cell injury or trauma. There are two closely related types of interleukins produced by the cell, IL-1α and IL-1β that are produced by the activation of NF-κ B transcription factor in response to bacterial infection or LPS. Both IL-1α and IL-1β exert their cellular effects by signalling through IL-1 receptor type 1. IL-1β has pleiotrophic activities and is protective against infections by recruitment of neutrophils to the infection site, secretion of cytokines and chemokines and activation of adhesion molecules. IL-1β overproduction has been implicated in many auto-immune and allergic disorders such as Cryopirin-associated periodic syndromes, Muckle-Wells syndrome and skin lesions
Anti-Interleukin-1β antibody specifically reacts with mouse IL-1β. The antibody shows 25% cross reactivity with human recombinant IL-1β.

特異性

本抗体はリコンビナントマウスIL-1βの生物活性を中和しますが、リコンビナントヒトIL-1βに対する中和活性はありません。 リコンビナントヒトIL-1βに対する抗体の交差反応性は約25%です。

免疫原

リコンビナントマウスIL-1β。

アプリケーション

Anti-interleukin-1β may be used to neutralize the biological activity of recombinant mouse IL-1β on mouse T-helper D10.G4.1 cell line at a concentration of 50 picog/ml. No neutralization of the biological activity of recombinant human IL-1β is observed. The antibody may be used for immunoblotting at a working concentration 1-2 μg/ml or a dilution of 1:1000. In immunoblotting applications the antibody shows 25% cross-reactivity with human recombinant IL-1β.

物理的形状

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing carbohydrates.

調製ノート

プロテインGを用いて精製しています。

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): Eyeshields, Gloves, type N95 (US)