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Merck

M1821

Sigma-Aldrich

Anti-Monoamine Oxidase B ウサギ宿主抗体

~1.5 mg/mL, affinity isolated antibody, buffered aqueous solution

別名:

Anti-Adrenalin oxidase, Anti-MAO, brain, Anti-MAO, platelet, Anti-Tyramine oxidase

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About This Item

UNSPSCコード:
12352203
NACRES:
NA.41

由来生物

rabbit

品質水準

結合体

unconjugated

抗体製品の状態

affinity isolated antibody

抗体製品タイプ

primary antibodies

クローン

polyclonal

形状

buffered aqueous solution

分子量

antigen ~58 kDa

化学種の反応性

mouse, rat, human

濃度

~1.5 mg/mL

テクニック

western blot: 0.5-1.0 μg/mL using rat liver mitochondrial fraction

UniProtアクセッション番号

輸送温度

dry ice

保管温度

−20°C

ターゲットの翻訳後修飾

unmodified

遺伝子情報

詳細

Monoamine Oxidase B (MAO-B) is a mitochondrial flavo enzyme. It is mainly found in the brain in dopaminergic, serotonergic, and histaminergic neurons and astrocytes.
Monoamine Oxidase B is encoded by the gene mapped to human chromosome Xp11.3.

特異性

Anti-Monoamine Oxidase B specifically recognizes human, mouse, and rat MAO-B.

アプリケーション

Anti-Monoamine Oxidase B antibody has been used in western blotting.
Anti-Monoamine Oxidase B antibody produced in rabbit has also been used in coimmunoprecipitation (co-IP) and immunohistochemistry.

生物化学的/生理学的作用

Monoamine oxidase B (MAO-B) is considered the predominant isoform responsible for dopamine metabolism in the human central nervous system (CNS). MAO-B activity correlates with personality traits. Alterations in MAO-B activity may underlie dopamine pathobiology in major depression. Selective MAO-B inhibitors elevate synaptosomal dopamine concentrations, and have recently shown clinical efficacy in the treatment of early Parkinson′s disease.

物理的形状

0.01 M PBS溶液 (pH 7.4, 15 mM アジ化ナトリウム含有)。

保管および安定性

For continuous use, store at 2–8 °C for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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保管分類コード

10 - Combustible liquids

引火点(°F)

Not applicable

引火点(℃)

Not applicable

個人用保護具 (PPE)

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)


適用法令

試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。

Jan Code

M1821-VAR:
M1821-200UL:
M1821-25UL:
M1821-BULK:
IXO14339:


試験成績書(COA)

製品のロット番号・バッチ番号を入力して、試験成績書(COA) を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。

以前この製品を購入いただいたことがある場合

文書ライブラリで、最近購入した製品の文書を検索できます。

文書ライブラリにアクセスする

Rasagiline [N-propargyl-1R (+)-aminoindan], a selective and potent inhibitor of mitochondrial monoamine oxidase B
Youdim M, et al.
British Journal of Pharmacology, 132(2), 500-506 (2001)
Structure of human monoamine oxidase B, a drug target for the treatment of neurological disorders
Binda C, et al.
Nature Structural and Molecular Biology, 9(1), 22-22 (2002)
Immunocytochemical demonstration of monoamine oxidase B in brain astrocytes and serotonergic neurons
Levitt P, et al.
Proceedings of the National Academy of Sciences of the USA, 79(20), 6385-6389 (1982)
Ryan E O'Leary et al.
European journal of medical genetics, 55(5), 349-353 (2012-03-01)
Monoamine oxidase A and B (MAOA and MAOB) play key roles in deaminating neurotransmitters and various other biogenic amines. Patients deficient in one or both enzymes have distinct metabolic and neurologic profiles. MAOB deficient patients exhibit normal clinical characteristics and
Sophia Schedin-Weiss et al.
Alzheimer's research & therapy, 9(1), 57-57 (2017-08-03)
Increased levels of the pathogenic amyloid β-peptide (Aβ), released from its precursor by the transmembrane protease γ-secretase, are found in Alzheimer disease (AD) brains. Interestingly, monoamine oxidase B (MAO-B) activity is also increased in AD brain, but its role in

ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.

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