RAB1317

Human Cathepsin D ELISA

for serum, plasma and cell culture supernatants

• 別名: Cathepsin D
• UNSPSCコード: 41116158
• NACRES: NA.32

特性

• 化学種の反応性: human
• 包装: kit of 96 wells (12 strips x 8 wells)
• テクニック: ELISA: suitable
• 入力: sample type cell culture supernatant(s); sample type plasma; sample type serum
• assay range: inter-assay cv: <12%; intra-assay cv: <10%; sensitivity: 50 pg/mL; standard curve range: 0.049-12 ng/mL
• 検出方法: colorimetric
• 輸送温度: wet ice
• 保管温度: −20°C
• 遺伝子情報: human ... CTSD(1509)

詳細

詳細

This ELISA antibody pair detects human Cathepsin D. Other species not yet determined.

アプリケーション

For research use only. Not for use in diagnostic procedures.
Please refer to the attached Protocolfor details.

生物化学的／生理学的作用

Cathepsin D encoded by CTSD gene, is an aspartyl protease, plays a major role in degradation of intracellular and endocytosed protein, for maintenance of tissue homeostasis and metabolism. Cathepsin D works as an endopeptidase in the acidic environment of lysosomes. Cathepsin D is part of signal transduction and a potential target for various cancer. Increased levels of Cathepsin D is associated with type 2 diabetes. Cathepsin D regulates sphingolipid metabolism and cholesterol trafficking. Genetic variations in Cathepsin D gene is a risk factor for Alzheimer′s disease and neuronal ceroid lipofuscinosis. Cathepsin D is a key marker in atherosclerosis and level of expression is increased in atherosclerotic lesions. Cathepsin D regulates the degradation of advanced glycation end products (AGEs) and impaired activity of cathepsin D results in accumulation of AGEs in photoaged skin. Increased plasma concentration of Cathepsin D causes non-alcoholic steatohepatitis (NASH) leading to hepatic lipid accumulation and inflammation.

その他情報

A sample Certificate of Analysis is available for this product. Please type the word sample in the text box provided for lot number.

安全性情報

• ピクトグラム: GHS05
• シグナルワード: Warning
• 危険有害性情報: H290
• 注意書き: P234 - P390
• 危険有害性の分類: Met. Corr. 1
• 保管分類コード: 8A - Combustible corrosive hazardous materials
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable