SAB4300345

Anti-ESR1 (Ab-106) antibody produced in rabbit

affinity isolated antibody

• 別名: 抗DKFZp686N23123抗体 ウサギ宿主抗体, 抗ER抗体 ウサギ宿主抗体, 抗ESRA抗体 ウサギ宿主抗体, 抗ESR抗体 ウサギ宿主抗体
• UNSPSCコード: 12352203
• NACRES: NA.41
• 結合体: unconjugated
• application: IHC (p); WB
• クローン: polyclonal
• 化学種の反応性: human, rat, mouse
• citations: 8
• テクニック: immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100; western blot: 1:500-1:1000

特性

• 由来生物: rabbit
• 品質水準: 100
• 結合体: unconjugated
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• フォーム: buffered aqueous solution
• 分子量: ~66 kDa
• 化学種の反応性: human, rat, mouse
• 濃度: 1 mg/mL
• テクニック: immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100; western blot: 1:500-1:1000
• アイソタイプ: IgG
• 免疫原配列: (S-P-S-P-L)
• NCBIアクセッション番号: NP_000116.2
• UniProtアクセッション番号: P03372
• 輸送温度: wet ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... ESR1(2099)

詳細

詳細

Estrogen receptor 1 (ESR1) encodes estrogen receptor α (ERα) protein, otherwise known as nuclear receptor subfamily 3, group A, member 1 (NR3A1), binds to estrogen. High expression of ERα is observed in tissues such as the epididymis, uterus, kidney and adrenal glands. In human chromosome, the gene ESR1 is localized on 6q25.1-q25.2.

免疫原

Peptide sequence around aa. 104-108 (S-P- S-P-L), according to the protein ESR1.

生物化学的／生理学的作用

Estrogen receptor 1 (ESR1) interacts with the nuclear transcription factor Sp1 in the presence of estradiol and regulates expression of diverse cellular and viral genes. ESR1 upon activation by estradiol interacts with transcription factor Sp3 and down regulates vascular endothelial growth factor (VEGF) in endometrial cancer cells. ESR1 tethers to DNA by protein-protein interaction with other transcription factor like activator protein 1 (AP1) family members like c-Jun, c-Fos and activating transcription factor (ATF). ESR1 and NF-κB cooperatively upregulates anti-apoptotic Baculoviral IAP (inhibitor of apoptosis protein) Repeat Containing 3 (BIRC3) and promotes breast cancer cell survival and tumor progression. Deleted in bladder cancer protein 1 (DBC1) modulates the expression of ESR1 and may promote the proliferation of breast cancer tissues. Interleukin-6 expression is suppressed by ligand activated ESR1 through interaction with NF-κB and thereby inhibits osteoporosis. ESR1 is potent in maintaining human immunodeficiency virus (HIV) latency and it is noted that latency maintenance and the amount of HIV RNA is gender specific, since women are more sensitive to estrogen.

特徴および利点

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ターゲットの説明

Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.

物理的形状

PBS（0.02％ アジ化ナトリウム、50％ グリセロール含有）

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable