SAB4501648

Anti-C-KIT antibody produced in rabbit

affinity isolated antibody

• 別名: SCFR
• MDL番号: MFCD00282164
• UNSPSCコード: 12352203
• NACRES: NA.41

特性

• 由来生物: rabbit
• 品質水準: 100
• 結合体: unconjugated
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• 形状: buffered aqueous solution
• 分子量: antigen 109 kDa
• 化学種の反応性: rat, mouse, human
• 濃度: ~1 mg/mL
• テクニック: ELISA: 1:10000; western blot: 1:500-1:1000
• NCBIアクセッション番号: P10721
• UniProtアクセッション番号: P10721
• 輸送温度: wet ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... KIT(3815)

詳細

詳細

Anti-C-KIT Antibody detects endogenous levels of total C-KIT protein.

KIT (proto-oncogene) is a type III receptor tyrosine kinase (RTK). It codes for a tyrosine kinase receptor (CD117). It is located on human chromosome 4q12.

The KIT (proto-oncogene receptor tyrosine kinase) gene is mapped to human chromosome 4q12. It encodes for a transmembrane glycoprotein that belongs to the receptor tyrosine kinases subclass III family.

免疫原

The antiserum was produced against synthesized peptide derived from human c-Kit.

Immunogen Range: 688-737

生物化学的／生理学的作用

KIT (proto-oncogene receptor tyrosine kinase) is considered to be an important hematopoietic growth factor receptor. It is known to exhibit tyrosine kinase activity that is associated with a variety of biologic processes, such as cell proliferation, survival, apoptosis, and motility. Downregulation of this gene is observed during the disease progression of multiple myeloma. Variation in the gene contributes to at least 2% of all melanomas and is most frequently observed in acral and mucosal melanomas. Mutations in KIT is associated with gastrointestinal stromal tumors.

KIT (proto-oncogene) participates in cell signal transduction. It also participates in the progression of hematopoietic stem cells, melanocytes, germ cells, mast cells and interstitial cells of Cajal. Mutations in KIT gene results in gastrointestinal stromal tumors.

特徴および利点

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物理的形状

ウサギIgGのPBS溶液（Mg2+およびCa2+を含まず）、pH 7.4、150 mM NaCl、0.02％ アジ化ナトリウム、50％ グリセロール

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: nwg
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable