SAB5702238

Anti-PD-L1/CD274 Antibody, clone 8F1V6, Rabbit Monoclonal

• 別名: B7-H,B7H1,PDL1,PD-L1,PDCD1L1,PDCD1LG1,CD274
• UNSPSCコード: 12352203
• NACRES: NA.46

特性

• 由来生物: rabbit
• 品質水準: 100
• 物質: colorless
• クローン: 8F1V6, monoclonal
• 形状: liquid
• 化学種の反応性: human
• 濃度: 0.65 mg/mL
• テクニック: flow cytometry: 1:50 - 1:200
• 色: colorless
• アイソタイプ: IgG
• UniProtアクセッション番号: Q9NZQ7
• 輸送温度: wet ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... PD-L1(29126)

詳細

詳細

Programmed death-ligand 1 (PD-L1) is a 40kDa type 1 transmembrane protein that suppresses immune system. PD-L1 is expressed in hematopoietic and non-hematopoietic cells including T cells and B cells and various types of tumor cells. PD-L1 binds to its receptor Programmed death 1 (PD1). During infection or inflammation, PD1-PD-L1 interaction is important for preventing autoimmunity. In tumor microenvironments, PD1-PD-L1 interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human cancers. In recent years, PD-L1 has become an important biomarker and immunotherapy target for many types of malignancies.

免疫原

PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.

Recombinant protein of human PD-L1/CD274.

アプリケーション

ELISA, WB, FC, Inhibition

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 1