SML0212

PSB36

≥98% (HPLC)

• 別名: 1-Butyl-3-(3-hydroxypropyl)-8-(3-noradamantyl)xanthine, 1-Butyl-8-(hexahydro-2,5-methanopentalen-3a(1H)-yl)-3,9-dihydro-3-(3-hydroxypropyl)-1H-purine-2,6-dione, PSB-36
• 実験式（ヒル表記法）: C₂₁H₃₀N₄O₃
• CAS番号: 524944-72-7
• 分子量: 386.49
• UNSPSCコード: 12352200
• PubChem Substance ID: 329825233
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• フォーム: powder
• 保管条件: desiccated
• 色: white to tan
• 溶解性: DMSO: ≥20 mg/mL
• 保管温度: 2-8°C
• SMILES記法: CCCCN1C(=O)N(CCCO)c2nc([nH]c2C1=O)C34C[C@@H]5C[C@@H](C[C@H]3C5)C4
• InChI: 1S/C21H30N4O3/c1-2-3-5-25-18(27)16-17(24(20(25)28)6-4-7-26)23-19(22-16)21-11-13-8-14(12-21)10-15(21)9-13/h13-15,26H,2-12H2,1H3,(H,22,23)/t13-,14+,15-,21-
• InChI Key: CIBIXJYFYPFMTN-FZUGUKJMSA-N

詳細

アプリケーション

PSB36 was used to examine the role of A1-adenosine receptor-mediated cell signaling in CD39 expression in pancreatic b-cells of streptozotocin-induced diabetic mice.

生物化学的／生理学的作用

Inhibition of A1 adenosine receptor by PSB36 modulates the spinal antinociception in animal models.

PSB36 is a very potent, selective antagonist of the adenosine A1 receptor. The compound selectivity (Ki) for human A1, A2A, A2B and A3 receptors is 0.7, 980, 187 and 2300 respectively. PSB36 is considerably more potent that DPCPX (EC₅₀ 0.012 nM vs 2.9 nM)

特徴および利点

This compound is featured on the Adenosine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable